Literature DB >> 6418247

Inhibition of lymphocyte activation by gold sodium thiomalate.

S J Hopkins, M I Jayson, P Van der Zeil.   

Abstract

Activation of lymphoid cells by both T and B cell mitogens was inhibited by gold sodium thiomalate (GST). The action of GST did not appear to be exerted at early stages of lymphocyte activation. Inhibition by GST was sustained throughout 4 days of culture. The inhibitory effect of GST was reduced at low serum concentrations. Sodium thiomalate and sodium chloroaurate were also able to inhibit lymphocyte activation.

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Year:  1983        PMID： 6418247      PMCID： PMC2044867          DOI： 10.1111/j.1476-5381.1983.tb11037.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  16 in total

1.  Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.

Authors:  C J Danpure; D A Fyfe; J M Gumpel
Journal:  Ann Rheum Dis       Date:  1979-08       Impact factor: 19.103

2.  Inhibition of pokeweed mitogen-induced immunoglobulin production in humans by gold compounds.

Authors:  S A Rosenberg; P E Lipsky
Journal:  J Rheumatol Suppl       Date:  1979

Review 3.  Activation of T-cells by a macrophage or 2-mercaptoethanol activated serum factor is essential for induction of a primary immune response to heterologous red cells in vitro.

Authors:  H G Opitz; H Lemke; G Hewlett
Journal:  Immunol Rev       Date:  1978       Impact factor: 12.988

Review 4.  Elicitation of selective T and B lymphocyte responses by cell surface binding ligands.

Authors:  M Greaves; G Janossy
Journal:  Transplant Rev       Date:  1972

5.  Inhibition by gold of human lymphocyte stimulation. An in vitro study.

Authors:  R B Lies; C Cardin; H E Paulus
Journal:  Ann Rheum Dis       Date:  1977-06       Impact factor: 19.103

6.  Interaction of D-penicillamine with gold salts: in vivo studies on gold chelation and in vitro studies on protein binding.

Authors:  P Davis; D Barraclough
Journal:  Arthritis Rheum       Date:  1977 Sep-Oct

7.  Effect of gold sodium thiomalate on murine lymphocyte functions.

Authors:  J J Jennings; S Macrae; R M Gorczynski
Journal:  Clin Exp Immunol       Date:  1979-05       Impact factor: 4.330

8.  The effects of mercaptoethanol and of peritoneal macrophages on the antibody-forming capacity of nonadherent mouse spleen cells in vitro.

Authors:  C Chen; J G Hirsch
Journal:  J Exp Med       Date:  1972-09-01       Impact factor: 14.307

9.  Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

Authors:  P E Lipsky; M Ziff
Journal:  J Clin Invest       Date:  1977-03       Impact factor: 14.808

10.  Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.

Authors:  J D Broome; M W Jeng
Journal:  J Exp Med       Date:  1973-09-01       Impact factor: 14.307
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