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Literature DB >> 6417263

Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2.

N Nogueira, G Kaplan, E Levy, E N Sarno, P Kushner, A Granelli-Piperno, L Vieira, V Colomer Gould, W Levis, R Steinman.

Abstract

Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6417263 PMCID： PMC2187179 DOI： 10.1084/jem.158.6.2165

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

15 in total

1. Studies on induction and effector functions of concanavalin A-induced suppressor cells that limit TCGF production.

Authors: M Gullberg; E L Larsson
Journal: J Immunol Date: 1982-02 Impact factor: 5.422

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Authors: P Sansonetti; P H Lagrange
Journal: Rev Infect Dis Date: 1981 May-Jun

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Authors: D S Ridley; W H Jopling
Journal: Int J Lepr Other Mycobact Dis Date: 1966 Jul-Sep

4. Partial purification and characterization of human gamma (immune) interferon.

Authors: Y K Yip; R H Pang; C Urban; J Vilcek
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

5. Gamma interferon induction in human thymocytes activated by lectins and B cell lines.

Authors: G H Reem; L A Cook; D M Henriksen; J Vilcek
Journal: Infect Immun Date: 1982-07 Impact factor: 3.441

6. Trypanosoma cruzi: induction of microbicidal activity in human mononuclear phagocytes.

Authors: N Nogueira; S Chaplan; M Reesink; J Tydings; Z A Cohn
Journal: J Immunol Date: 1982-05 Impact factor: 5.422

7. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes.

Authors: W C Van Voorhis; G Kaplan; E N Sarno; M A Horwitz; R M Steinman; W R Levis; N Nogueira; L S Hair; C R Gattass; B A Arrick; Z A Cohn
Journal: N Engl J Med Date: 1982-12-23 Impact factor: 91.245

8. T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function.

Authors: M Kramer; U Koszinowski
Journal: J Immunol Date: 1982-02 Impact factor: 5.422

9. Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity.

Authors: A Granelli-Piperno; J D Vassalli; E Reich
Journal: J Exp Med Date: 1981-08-01 Impact factor: 14.307

10. Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism.

Authors: K Inaba; A Granelli-Piperno; R M Steinman
Journal: J Exp Med Date: 1983-12-01 Impact factor: 14.307

52 in total

1. Quantitative assessment of tuftsin receptor expression and second messenger during in vitro differentiation of peripheral blood derived monocytes of leprosy patients.

Authors: S Khare; L K Bhutani; D N Rao
Journal: Mol Cell Biochem Date: 1997-06 Impact factor: 3.396

2. A single cell assay for the study of gamma-interferon formation in leprosy patients.

Authors: J Lindh; U Anderson; S Britton; M De Ley
Journal: Clin Exp Immunol Date: 1987-01 Impact factor: 4.330

3. Defective intralesional interferon-gamma activity in patients with lepromatous leprosy.

Authors: B Volc-Platzer; H Stemberger; T Luger; T Radaszkiewicz; G Wiedermann
Journal: Clin Exp Immunol Date: 1988-02 Impact factor: 4.330

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Authors: F Emmrich; S H Kaufmann
Journal: Infect Immun Date: 1986-03 Impact factor: 3.441

5. Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis.

Authors: J Vilcek; A Klion; D Henriksen-DeStefano; A Zemtsov; D M Davidson; M Davidson; A E Friedman-Kien; J Le
Journal: J Clin Immunol Date: 1986-03 Impact factor: 8.317

6. Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum.

Authors: S Laal; L K Bhutani; I Nath
Journal: Infect Immun Date: 1985-12 Impact factor: 3.441

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Authors: C Fiocchi; K R Youngman; B Yen-Lieberman; R R Tubbs
Journal: Dig Dis Sci Date: 1988-10 Impact factor: 3.199

8. Identification of an immunostimulating protein from Mycobacterium leprae.

Authors: N Mohagheghpour; M W Munn; R H Gelber; E G Engleman
Journal: Infect Immun Date: 1990-03 Impact factor: 3.441

9. Effect of multiple interferon gamma injections on the disposal of Mycobacterium leprae.

Authors: G Kaplan; N K Mathur; C K Job; I Nath; Z A Cohn
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

10. Influence of Mycobacterium leprae and its soluble products on the cutaneous responsiveness of leprosy patients to antigen and recombinant interleukin 2.

Authors: G Kaplan; E P Sampaio; G P Walsh; R A Burkhardt; T T Fajardo; L S Guido; A de Miranda Machado; R V Cellona; R M Abalos; E N Sarno
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205