Literature DB >> 6416344

Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue.

K A Clarke, G Stirk.   

Abstract

Recording have been made of motoneurone field potentials at vertebral level L1 to stimulation of the ventral root, in rats anaesthetized with urethane. Injection of thyrotrophin releasing hormone (TRH) analogue RX77368 (2 mg kg-1) produced an increase in the amplitude of the field potential within 1 min of injection, reaching peak amplitude of 51-69% above control values 6-12 min after injection; the duration of the elevation was 30-65 min. Arguments are presented which show that this effect is compatible with an RX77368-induced depolarization of the motoneurone, allowing the antidromic volley to invade more cell bodies.

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Year:  1983        PMID： 6416344      PMCID： PMC2045012          DOI： 10.1111/j.1476-5381.1983.tb10729.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Electric potentials generated by antidromic volleys in quadriceps and hamstring motoneurons.

Authors:  T H BARAKAN; C B B DOWNMAN; J C ECCLES
Journal:  J Neurophysiol       Date:  1949-11       Impact factor: 2.714

2.  Excitatory action of TRH on spinal motoneurones.

Authors:  R A Nicoll
Journal:  Nature       Date:  1977-01-20       Impact factor: 49.962

3.  TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats.

Authors:  A R Green; D G Grahame-Smith
Journal:  Nature       Date:  1974-10-11       Impact factor: 49.962

4.  The responses of motoneurones to 5-hydroxytryptamine.

Authors:  O Parry; M H Roberts
Journal:  Neuropharmacology       Date:  1980-06       Impact factor: 5.250

5.  Induction of wet-dog shaking in rats by analogues and metabolites of thyrotrophin-releasing hormone (TRH).

Authors:  V A Webster; E C Griffiths; P Slater
Journal:  Regul Pept       Date:  1982-12

6.  Serotonergic facilitation of facial motoneuron excitation.

Authors:  R B McCall; G K Aghajanian
Journal:  Brain Res       Date:  1979-06-15       Impact factor: 3.252

7.  Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord.

Authors:  H Ono; H Fukuda
Journal:  Neuropharmacology       Date:  1982-08       Impact factor: 5.250

8.  Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord.

Authors:  C A Marsden; G W Bennett; J Irons; R F Gilbert; P C Emson
Journal:  Comp Biochem Physiol C       Date:  1982
  8 in total
  5 in total

1.  Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.

Authors:  R J Guiloff; H Modarres-Sadeghi; E Stålberg; H Rogers
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-05       Impact factor: 10.154

2.  Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.

Authors:  R J Guiloff; D J Eckland; C Demaine; R C Hoare; K D MacRae; S L Lightman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-10       Impact factor: 10.154

3.  Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).

Authors:  R J Guiloff; E Stålberg; D J Eckland; S L Lightman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-12       Impact factor: 10.154

4.  Involvement of 5-HT2 receptors in the behaviours produced by intrathecal administration of selected 5-HT agonists and the TRH analogue (CG 3509) to rats.

Authors:  K C Fone; J V Johnson; G W Bennett; C A Marsden
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

5.  Down-regulation of thyrotropin-releasing hormone (TRH) receptors in spinal cord after transection as revealed by quantitative autoradiography.

Authors:  G Vita; C K Haun; E F Hawkins; W K Engel
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972
  5 in total

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