Literature DB >> 3125307

Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).

R J Guiloff1, E Stålberg, D J Eckland, S L Lightman.   

Abstract

Twenty nine patients with motor neuron disease receiving a thyrotropin releasing hormone analogue showed acute 25-30% increase in mean corrected fibre density and mean macro EMG median amplitude and area in brachial biceps muscle. The data are consistent with a direct or indirect action of the drug on anterior horn cells.

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Year:  1987        PMID： 3125307      PMCID： PMC1032605          DOI： 10.1136/jnnp.50.12.1633

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  20 in total

1.  Stimulant action of thyrotropin releasing hormone on cat spinal cord.

Authors:  B R Cooper; C E Boyer
Journal:  Neuropharmacology       Date:  1978-02       Impact factor: 5.250

2.  Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?

Authors:  G Metcalf; P W Dettmar
Journal:  Lancet       Date:  1981-03-14       Impact factor: 79.321

3.  The two-period cross-over clinical trial.

Authors:  M Hills; P Armitage
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

4.  Biologically stable analogues of TRH with increased neuropharmacological potency.

Authors:  D Brewster; P W Dettmar; G Metcalf
Journal:  Neuropharmacology       Date:  1981-05       Impact factor: 5.250

5.  Excitatory action of TRH on spinal motoneurones.

Authors:  R A Nicoll
Journal:  Nature       Date:  1977-01-20       Impact factor: 49.962

6.  Macro EMG, a new recording technique.

Authors:  E Stålberg
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-06       Impact factor: 10.154

7.  Actions of various gastrointestinal peptides on the isolated amphibian spinal cord.

Authors:  J W Phillis; J R Kirkpatrick
Journal:  Can J Physiol Pharmacol       Date:  1979-08       Impact factor: 2.273

8.  Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability.

Authors:  G Metcalf; P W Dettmar; A G Lynn; D Brewster; M E Havler
Journal:  Regul Pept       Date:  1981-09

9.  Neuropharmacological evaluation of RX 77368--a stabilised analogue of thyrotropin-releasing hormone (TRH).

Authors:  G Metcalf; P W Dettmar; D Fortune; A G Lynn; I F Tulloch
Journal:  Regul Pept       Date:  1982-03

10.  Electrophysiological cross section of the motor unit.

Authors:  E Stålberg; L Antoni
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-06       Impact factor: 10.154
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  2 in total

1.  Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.

Authors:  R J Guiloff; H Modarres-Sadeghi; E Stålberg; H Rogers
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-05       Impact factor: 10.154

2.  Pharmacological and biochemical comparison of thyrotropin releasing hormone (TRH) and di-methyl proline-TRH on pituitary GH3 cells.

Authors:  A M McDermott; G P Wilkin; S L Dickinson
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739
  2 in total

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