Literature DB >> 6415235

Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus.

O Hara, S Horinouchi, T Uozumi, T Beppu.   

Abstract

A-factor is a potent pleiotropic effector produced by Streptomyces griseus and is essential for streptomycin production and spore formation in this organism. Its production is widely distributed among various actinomycetes including Streptomyces coelicolor A3(2). Genetic analysis of A-factor production was carried out with S. coelicolor A3(2), and two closely linked loci for A-factor mutations (afsA and B) were identified between cysD and leuB on the chromosomal linkage map. In contrast, genetic crosses of A-factor-negative mutants of S. griseus, using a protoplast fusion technique, failed to give a fixed locus for A-factor gene(s) and suggested involvement of an extrachromosomal or transposable genetic element in A-factor synthesis in this organism.

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Year:  1983        PMID： 6415235     DOI： 10.1099/00221287-129-9-2939

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  34 in total

1.  ATP-binding cassette transport system involved in regulation of morphological differentiation in response to glucose in Streptomyces griseus.

Authors:  Jeong-Woo Seo; Yasuo Ohnishi; Aiko Hirata; Sueharu Horinouchi
Journal:  J Bacteriol       Date:  2002-01       Impact factor: 3.490

2.  Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein.

Authors:  P Arias; M A Fernández-Moreno; F Malpartida
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

3.  Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.

Authors:  T Adamidis; W Champness
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

4.  Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans.

Authors:  N M Romero; V Parro; F Malpartida; R P Mellado
Journal:  Nucleic Acids Res       Date:  1992-06-11       Impact factor: 16.971

5.  Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus.

Authors:  D Vujaklija; K Ueda; S K Hong; T Beppu; S Horinouchi
Journal:  Mol Gen Genet       Date:  1991-09

6.  Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.

Authors:  Jun-ya Kato; Nobutaka Funa; Hidenori Watanabe; Yasuo Ohnishi; Sueharu Horinouchi
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-02       Impact factor: 11.205

7.  A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different developmental mutants.

Authors:  D Stein; S N Cohen
Journal:  J Bacteriol       Date:  1989-04       Impact factor: 3.490

8.  Unstable genetic determinant of A-factor biosynthesis in streptomycin-producing organisms: cloning and characterization.

Authors:  S Horinouchi; Y Kumada; T Beppu
Journal:  J Bacteriol       Date:  1984-05       Impact factor: 3.490

9.  Cloning and characterization of the A-factor receptor gene from Streptomyces griseus.

Authors:  H Onaka; N Ando; T Nihira; Y Yamada; T Beppu; S Horinouchi
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

10.  Transcriptional regulation of Streptomyces coelicolor pathway-specific antibiotic regulators by the absA and absB loci.

Authors:  D J Aceti; W C Champness
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490
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