Literature DB >> 1614864

Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans.

N M Romero1, V Parro, F Malpartida, R P Mellado.   

Abstract

A DNA fragment of Streptomyces fradiae is able to activate the antibiotic actinorhodin biosynthetic pathway when cloned in Streptomyces lividans. The activator DNA region has been sequenced and its transcription initiation and termination sites accurately mapped in vivo. This DNA encodes a 132 nucleotides long transcript which is apparently responsible for the actinorhodin production phenotype, possibly acting as an antisense RNA. The sequence of the activator gene revealed no homology with any other known Streptomyces coelicolor genes concerned with actinorhodin biosynthesis or its pleiotropic regulation.

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Year:  1992        PMID： 1614864      PMCID： PMC336920          DOI： 10.1093/nar/20.11.2767

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  32 in total

1.  A Bacillus subtilis phage phi 29 transcription terminator is efficiently recognized in Streptomyces lividans.

Authors:  D Pulido; A Jiménez; M Salas; R P Mellado
Journal:  Gene       Date:  1987       Impact factor: 3.688

2.  In vivo transcription of bacteriophage phi 29 DNA: transcription termination.

Authors:  I Barthelemy; M Salas; R P Mellado
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

3.  Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor.

Authors:  K Ochi
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490

4.  The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. laevis.

Authors:  B Sollner-Webb; R H Reeder
Journal:  Cell       Date:  1979-10       Impact factor: 41.582

5.  In vivo transcription of bacteriophage phi 29 DNA: transcription initiation sites.

Authors:  I Barthelemy; M Salas; R P Mellado
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

6.  Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

Authors:  C Yanisch-Perron; J Vieira; J Messing
Journal:  Gene       Date:  1985       Impact factor: 3.688

7.  Transcription of genes involved in the earliest steps of actinorhodin biosynthesis in Streptomyces coelicolor.

Authors:  V Parro; D A Hopwood; F Malpartida; R P Mellado
Journal:  Nucleic Acids Res       Date:  1991-05-25       Impact factor: 16.971

8.  Construction and characterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator.

Authors:  J M Ward; G R Janssen; T Kieser; M J Bibb; M J Buttner; M J Bibb
Journal:  Mol Gen Genet       Date:  1986-06

9.  Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum as deduced from the cDNA sequence.

Authors:  J Kasir; R R Aksamit; P S Backlund; G L Cantoni
Journal:  Biochem Biophys Res Commun       Date:  1988-05-31       Impact factor: 3.575

10.  The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.

Authors:  M A Fernández-Moreno; J L Caballero; D A Hopwood; F Malpartida
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582
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  6 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-08-11       Impact factor: 16.971

2.  Identification of a novel unpaired histidine sensor kinase affecting secondary metabolism and morphological differentiation in Streptomyces acidiscabies ATCC 49003.

Authors:  Ji-Min Park; Sun-Uk Choi
Journal:  Folia Microbiol (Praha)       Date:  2015-03-29       Impact factor: 2.099

3.  Transcriptional regulation of Streptomyces coelicolor pathway-specific antibiotic regulators by the absA and absB loci.

Authors:  D J Aceti; W C Champness
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

4.  Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius.

Authors:  K Madduri; C R Hutchinson
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

5.  Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

Authors:  Gabriel C Uguru; Madhav Mondhe; Shan Goh; Andrew Hesketh; Mervyn J Bibb; Liam Good; James E M Stach
Journal:  PLoS One       Date:  2013-06-27       Impact factor: 3.240

6.  Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans.

Authors:  Karthik P Jayapal; Wei Lian; Frank Glod; David H Sherman; Wei-Shou Hu
Journal:  BMC Genomics       Date:  2007-07-10       Impact factor: 3.969
  6 in total

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