Literature DB >> 6414942

Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.

J E Kay, C R Benzie, A F Borghetti.   

Abstract

The activation of pig lymphocytes by the divalent cation ionophore A23187 is more sensitive to inhibition by cyclosporin A than is activation by plant lectins such as concanavalin A. Complete inhibition of A23187-induced activation was seen at a cyclosporin A concentration of 0.3 micrograms/ml. The very early stimulation of nucleoside uptake induced by A23187 was not affected by cyclosporin A, but other early metabolic changes occurring during the first few hours after activation were inhibited.

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Year:  1983        PMID： 6414942      PMCID： PMC1454254     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  24 in total

1.  Changes in intracellular prostaglandin content during activation of lymphocytes by phytohaemagglutinin.

Authors:  C A Phillips; E Z Girit; J E Kay
Journal:  FEBS Lett       Date:  1978-10-01       Impact factor: 4.124

2.  Enhanced uptake of calcium by transforming lymphocytes.

Authors:  R B Whitney; R M Sutherland
Journal:  Cell Immunol       Date:  1972-09       Impact factor: 4.868

3.  Kinetics of lymphocyte stimulation by concanavalin A.

Authors:  S Toyoshima; M Iwata; T Osawa
Journal:  Nature       Date:  1976-12-02       Impact factor: 49.962

4.  Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.

Authors:  E L Larsson
Journal:  J Immunol       Date:  1980-06       Impact factor: 5.422

5.  Effects of cyclosporin A on the metabolism of unstimulated and mitogen-activated lymphocytes.

Authors:  J E Kay; C R Benzie
Journal:  Immunology       Date:  1983-05       Impact factor: 7.397

6.  Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.

Authors:  A W Thomson; D K Moon; C L Geczy; D S Nelson
Journal:  Immunology       Date:  1983-02       Impact factor: 7.397

7.  Suppressive effects of cyclosporin A on the induction of alloreactivity in vitro and in vivo.

Authors:  B S Wang; E H Heacock; K H Collins; I F Hutchinson; N L Tilney; J A Mannick
Journal:  J Immunol       Date:  1981-07       Impact factor: 5.422

8.  Concanavalin A triggers T lymphocytes by directly interacting with their receptors for activation.

Authors:  R Palacios
Journal:  J Immunol       Date:  1982-01       Impact factor: 5.422

9.  Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in CsA-treated primary MLR cultures.

Authors:  A D Hess; P J Tutschka; Z Pu; G W Santos
Journal:  J Immunol       Date:  1982-01       Impact factor: 5.422

10.  Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.

Authors:  D Bunjes; C Hardt; M Röllinghoff; H Wagner
Journal:  Eur J Immunol       Date:  1981-08       Impact factor: 5.532
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  12 in total

1.  Functional differentiation of human cytotoxic T lymphocytes in the presence of FK 506 and CyA.

Authors:  A Zeevi; G Eiras; F H Bach; J J Fung; S Todo; T Starzl; R J Duquesnoy
Journal:  Transplant Proc       Date:  1990-02       Impact factor: 1.066

2.  Activation and proliferation signals in mouse B cells. VII. Calcium ionophores are non-mitogenic polyclonal B-cell activators.

Authors:  G G Klaus; M K Bijsterbosch; M Holman
Journal:  Immunology       Date:  1985-10       Impact factor: 7.397

3.  Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

Authors:  R J Bram; D T Hung; P K Martin; S L Schreiber; G R Crabtree
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

Review 4.  The influence of cyclosporin A on cell-mediated immunity.

Authors:  A W Thomson; L M Webster
Journal:  Clin Exp Immunol       Date:  1988-03       Impact factor: 4.330

5.  Action of cyclosporine on mitochondrial calcium fluxes.

Authors:  N Fournier; G Ducet; A Crevat
Journal:  J Bioenerg Biomembr       Date:  1987-06       Impact factor: 2.945

6.  Cyclosporine does not inhibit mitogen-induced inositol phospholipid degradation in mouse lymphocytes.

Authors:  M K Bijsterbosch; G G Klaus
Journal:  Immunology       Date:  1985-11       Impact factor: 7.397

Review 7.  Neural roles of immunophilins and their ligands.

Authors:  D M Sabatini; M M Lai; S H Snyder
Journal:  Mol Neurobiol       Date:  1997-10       Impact factor: 5.590

8.  Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.

Authors:  E J Griffiths; A P Halestrap
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

Review 9.  Regulation of lymphocyte growth by antagonists of interleukin-2 or its cellular receptor.

Authors:  G N Gaulton; J F Markmann
Journal:  Immunol Res       Date:  1988       Impact factor: 2.829

10.  Lymphocyte activation by OKT3: cyclosporine sensitivity and synergism with phorbol ester.

Authors:  J E Kay; C R Benzie
Journal:  Immunology       Date:  1986-02       Impact factor: 7.397
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