Literature DB >> 6413529

Rocky Mountain spotted fever vaccine in an animal model.

J D Folds, D H Walker, B C Hegarty, D Banasiak, J V Lange.   

Abstract

Formalin-killed, purified Rickettsia rickettsii vaccine was evaluated in a guinea pig model of R. rickettsii infection. Vaccinated guinea pigs were partially protected by the vaccine when challenged with virulent, viable rickettsiae. Greater protection was observed when higher doses of vaccine were given and when frequent booster injections were administered. Stimulation of cell-mediated immunity to the vaccine antigens was variable and also appeared to be achieved more reproducibly with booster vaccinations. Serum antibody was elicited by high doses of vaccine and by booster vaccinations. The presence of serum antibody was useful in predicting immunity to challenge with R. rickettsii.

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Year:  1983        PMID： 6413529      PMCID： PMC270799          DOI： 10.1128/jcm.18.2.321-326.1983

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  10 in total

1.  Public Health Weekly Reports for OCTOBER 9, 1925.

Authors: 
Journal:  Public Health Rep       Date:  1925-10-09       Impact factor: 2.792

2.  Initial clinical evaluation of a new Rocky Mountain spotted fever vaccine of tissue culture origin.

Authors:  M S Ascher; C N Oster; P I Harber; R H Kenyon; C E Pedersen
Journal:  J Infect Dis       Date:  1978-08       Impact factor: 5.226

3.  Selective in vitro response of thymus-derived lymphocytes from Treponema pallidum-infected rabbits.

Authors:  C S Pavia; J D Folds; J B Baseman
Journal:  Infect Immun       Date:  1977-12       Impact factor: 3.441

4.  Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.

Authors:  R H Kenyon; C E Pedersen
Journal:  J Clin Microbiol       Date:  1975-06       Impact factor: 5.948

Review 5.  Signals regulating in vitro activation of lymphocytes.

Authors:  J J Oppenheim; D L Rosenstreich
Journal:  Prog Allergy       Date:  1976

6.  Exposure of guinea pigs to Rickettsia rickettsii by aerosol, nasal, conjunctival, gastric, and subcutaneous routes and protection afforded by an experimental vaccine.

Authors:  R H Kenyon; R A Kishimoto; W C Hall
Journal:  Infect Immun       Date:  1979-08       Impact factor: 3.441

7.  Functional and morphologic changes during experimental Rocky Mountain spotted fever in guinea pigs.

Authors:  J B Moe; D F Mosher; R H Kenyon; J D White; J L Stookey; L R Bagley; D P Fine
Journal:  Lab Invest       Date:  1976-09       Impact factor: 5.662

8.  Microimmunofluorescence test for the serological study of rocky mountain spotted fever and typhus.

Authors:  R N Philip; E A Casper; R A Ormsbee; M G Peacock; W Burgdorfer
Journal:  J Clin Microbiol       Date:  1976-01       Impact factor: 5.948

9.  Suppression of cellular immune responses in guinea pigs infected with spotted fever group rickettsiae.

Authors:  C N Oster; R H Kenyon; C E Pedersen
Journal:  Infect Immun       Date:  1978-11       Impact factor: 3.441

10.  In vitro guinea pig leukocyte reactions to Rickettsia rickettsii.

Authors:  R H Kenyon; M S Ascher; R A Kishimoto; C E Pedersen
Journal:  Infect Immun       Date:  1977-12       Impact factor: 3.441
  10 in total
  2 in total

1.  Effects of homologous and heterologous immunization on the reservoir competence of domestic dogs for Rickettsia conorii (israelensis).

Authors:  M L Levin; G E Zemtsova; M Montgomery; L F Killmaster
Journal:  Ticks Tick Borne Dis       Date:  2013-11-05       Impact factor: 3.744

2.  Surface proteome analysis and characterization of surface cell antigen (Sca) or autotransporter family of Rickettsia typhi.

Authors:  Khandra T Sears; Shane M Ceraul; Joseph J Gillespie; Edwin D Allen; Vsevolod L Popov; Nicole C Ammerman; M Sayeedur Rahman; Abdu F Azad
Journal:  PLoS Pathog       Date:  2012-08-09       Impact factor: 6.823
  2 in total

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