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Literature DB >> 6408663

Tricyclic plasma levels in depressed outpatients treated with amitriptyline.

Abstract

Seventy-four patients were treated with 150 mg/day amitriptyline (AT) to determine possible correlations between clinical improvement, demographic variables, and AT and nortriptyline (NT) plasma levels. Plasma level determinations after 2 and 6 weeks of treatment revealed that moderately significant correlations existed between AT plasma levels and clinical improvement, dosage intake, age, weight, sex, and coffee intake. Some of these findings were more pronounced after 2, and some after 6 weeks of treatment.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6408663 DOI： 10.1007/BF00427486

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

25 in total

1. Rapid, sensitive gas-liquid chromatographic method for determination of amitryptyline and nortriptyline in plasma using a nitrogen-sensitive detector.

Authors: H B Hucker; S C Stauffer
Journal: J Chromatogr Date: 1977-08-11

2. The physician depression scale (PDS): a factor analytic study.

Authors: K Rickels; R W Downing; H Spaeth
Journal: Pharmakopsychiatr Neuropsychopharmakol Date: 1973-11

3. A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.

Authors: J Mendlewicz; P Linkowski; J A Rees
Journal: Br J Psychiatry Date: 1980-02 Impact factor: 9.319

4. Effect of alcohol consumption and cigarette smoking on antidepressant levels of depressed patients.

Authors: M Linnoila; L George; S Guthrie; B Leventhal
Journal: Am J Psychiatry Date: 1981-06 Impact factor: 18.112

5. Amitriptyline plasma levels and clinical response in primary depression.

Authors: D J Kupfer; I Hanin; D G Spiker; T Grau; P Coble
Journal: Clin Pharmacol Ther Date: 1977-12 Impact factor: 6.875

6. Amitriptyline plasma levels and therapeutic response.

Authors: V E Ziegler; B T Co; J R Taylor; P J Clayton; J T Biggs
Journal: Clin Pharmacol Ther Date: 1976-06 Impact factor: 6.875

7. Amitriptyline once daily vs three times daily in depressed outpatients.

Authors: C C Weise; M K Stein; J Pereira-Ogan; I Csanalosi; K Rickels
Journal: Arch Gen Psychiatry Date: 1980-05

8. Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II.

Authors: S C Risch; L Y Huey; D S Janowsky
Journal: J Clin Psychiatry Date: 1979-02 Impact factor: 4.384

9. On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.

Authors: G Jungkunz; H J Kuss
Journal: Pharmakopsychiatr Neuropsychopharmakol Date: 1980-05

10. Amitriptyline plasma-concentration and clinical effect. A World Health Organisation Collaborative Study.

Authors: A Coppen; K Ghose; S Montgomery; V A Rama Rao; J Bailey; J Christiansen; P L Mikkleson; H M van Praag; F van de Poel; E J Minsker; V G Kozulja; N Matussek; G Kungkunz; A Jłrgensen
Journal: Lancet Date: 1978-01-14 Impact factor: 79.321

7 in total

1. Comprehensive survey of the relationship between serum concentration and therapeutic effect of amitriptyline in depression.

Authors: Sven Ulrich; Jürgen Läuter
Journal: Clin Pharmacokinet Date: 2002 Impact factor: 6.447

Tricyclic plasma levels in depressed outpatients treated with amitriptyline.

1. Rapid, sensitive gas-liquid chromatographic method for determination of amitryptyline and nortriptyline in plasma using a nitrogen-sensitive detector.

2. The physician depression scale (PDS): a factor analytic study.

3. A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.

4. Effect of alcohol consumption and cigarette smoking on antidepressant levels of depressed patients.

5. Amitriptyline plasma levels and clinical response in primary depression.

6. Amitriptyline plasma levels and therapeutic response.

7. Amitriptyline once daily vs three times daily in depressed outpatients.

8. Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II.

9. On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.

10. Amitriptyline plasma-concentration and clinical effect. A World Health Organisation Collaborative Study.

1. Comprehensive survey of the relationship between serum concentration and therapeutic effect of amitriptyline in depression.

Review 2. Discrepancies between pharmacokinetic studies of amitriptyline.

Review 3. Pharmacokinetic optimisation of tricyclic antidepressant therapy.

4. Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants.

Review 5. Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective.

Review 6. Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications.

7. Antidepressive effect of amitriptyline treatment with plasma drug levels controlled within three different ranges.