Literature DB >> 6405386

In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor.

M K Waldor, S Sriram, H O McDevitt, L Steinman.   

Abstract

A monoclonal antibody to I-A gene products of the immune response gene complex attenuates both humoral and cellular responses to acetylcholine receptor and appears to suppress clinical manifestations of experimental autoimmune myasthenia gravis. This demonstrates that use of antibodies against immune response gene products that are associated with susceptibility to disease may be feasible for therapy in autoimmune conditions such as myasthenia gravis.

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Year:  1983        PMID： 6405386      PMCID： PMC393898          DOI： 10.1073/pnas.80.9.2713

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Strain differences in the autoimmune response of mice to acetylcholine receptors.

Authors:  S Fuchs; D Nevo; R Tarrab-Hazdai; I Yaar
Journal:  Nature       Date:  1976-09-23       Impact factor: 49.962

2.  Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis.

Authors:  P C Dau; J M Lindstrom; C K Cassel; E H Denys; E E Shev; L E Spitler
Journal:  N Engl J Med       Date:  1977-11-24       Impact factor: 91.245

3.  A simple assay for the study of solubilized acetylcholine receptors.

Authors:  J Schmidt; M A Raftery
Journal:  Anal Biochem       Date:  1973-04       Impact factor: 3.365

4.  Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

Authors:  V T Oi; P P Jones; J W Goding; L A Herzenberg; L A Herzenberg
Journal:  Curr Top Microbiol Immunol       Date:  1978       Impact factor: 4.291

5.  Effect of sodium salicylate on human and mouse granulopoiesis in vitro.

Authors:  J D Gabourel; M A Moore; G C Bagby; G H Davies
Journal:  Arthritis Rheum       Date:  1977 Jan-Feb

6.  Induction of anti-idiotypic antibodies by immunisation with syngeneic spleen cells educated with acetylcholine receptor.

Authors:  M Schwartz; D Novick; D Givol; S Fuchs
Journal:  Nature       Date:  1978-06-15       Impact factor: 49.962

7.  Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.

Authors:  M I Greene; M E Dorf; M Pierres; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

8.  Modulation of acetylcholine receptor by antibody against the receptor.

Authors:  S Heinemann; S Bevan; R Kullberg; J Lindstrom; J Rice
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

9.  Myasthenic immunoglobulin accelerates acetylcholine receptor degradation.

Authors:  I Kao; D B Drachman
Journal:  Science       Date:  1977-04-29       Impact factor: 47.728

10.  Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies.

Authors:  L L Perry; M I Greene
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307
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  33 in total

Review 1.  Astrocytes and intracerebral immune responses.

Authors:  E M Frohman; S van den Noort; S Gupta
Journal:  J Clin Immunol       Date:  1989-01       Impact factor: 8.317

2.  Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms.

Authors:  E M Frohman; B Vayuvegula; S Gupta; S van den Noort
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

Review 3.  New therapeutic approaches to autoimmune disease.

Authors:  N Talal
Journal:  Springer Semin Immunopathol       Date:  1986

4.  Experimental autoimmune myasthenia gravis in the mouse.

Authors:  B Wu; E Goluszko; P Christadoss
Journal:  Curr Protoc Immunol       Date:  2001-05

Review 5.  Monoclonal antibodies as magic bullets.

Authors:  F M Brodsky
Journal:  Pharm Res       Date:  1988-01       Impact factor: 4.200

Review 6.  Premises for immune interventional therapy in rheumatoid arthritis.

Authors:  I R Mackay; M J Rowley
Journal:  Postgrad Med J       Date:  1988-07       Impact factor: 2.401

7.  Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

Authors:  C Boitard; A Bendelac; M F Richard; C Carnaud; J F Bach
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

Review 8.  Myasthenia gravis--current concepts.

Authors:  C Herrmann; J M Lindstrom; J C Keesey; D G Mulder
Journal:  West J Med       Date:  1985-06

Review 9.  Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal.

Authors:  Lawrence Steinman
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

10.  Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies.

Authors:  G G Oliveira; P R Hutchings; I M Roitt; P M Lydyard
Journal:  Clin Exp Immunol       Date:  1994-05       Impact factor: 4.330
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