Literature DB >> 8187337

Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies.

G G Oliveira1, P R Hutchings, I M Roitt, P M Lydyard.   

Abstract

NZB mice spontaneously develop haemolytic anaemia as the result of production of erythrocyte autoantibodies. The mechanisms leading to breakdown in tolerance to erythrocyte autoantigens are unknown. Antibodies to CD4 have been successfully used to treat several murine models of autoimmune disease. In this study we injected NZB mice with non-depleting CD4 antibodies and were able to prevent and abrogate erythrocyte autoantibody production in young (Coombs' negative) and old (Coombs' positive) mice, respectively. Our data indicate the dependency of autoantibody production on CD4+ T cells. However, withdrawal of anti-CD4 antibodies resulted in the appearance of erythrocyte autoantibodies, showing that under these conditions we were unable to re-establish tolerance to autoantigens on erythrocytes using anti-CD4 treatment.

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Year:  1994        PMID： 8187337      PMCID： PMC1534883          DOI： 10.1111/j.1365-2249.1994.tb06557.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  40 in total

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Journal:  Science       Date:  1988-04-29       Impact factor: 47.728

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Authors:  R J Benjamin; H Waldmann
Journal:  Nature       Date:  1986 Apr 3-9       Impact factor: 49.962

6.  Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice.

Authors:  T Koike; Y Itoh; T Ishii; I Ito; K Takabayashi; N Maruyama; H Tomioka; S Yoshida
Journal:  Diabetes       Date:  1987-04       Impact factor: 9.461

7.  Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte band 3 protein.

Authors:  R N Barker; G G de Sá Oliveira; C J Elson; P M Lydyard
Journal:  Eur J Immunol       Date:  1993-07       Impact factor: 5.532

8.  Anti-mouse red blood cell monoclonal antibodies use functionally rearranged genes from the VH J558 family and are derived from the CD5- B-lymphocyte subpopulation.

Authors:  B B Scott; S Sadigh; M Stow; R A Mageed; E M Andrew; R N Maini
Journal:  Immunology       Date:  1993-08       Impact factor: 7.397

9.  Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthritis patients.

Authors:  D Goldberg; P Morel; L Chatenoud; C Boitard; C J Menkes; P H Bertoye; J P Revillard; J F Bach
Journal:  J Autoimmun       Date:  1991-08       Impact factor: 7.094

10.  Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody.

Authors:  G Horneff; G R Burmester; F Emmrich; J R Kalden
Journal:  Arthritis Rheum       Date:  1991-02
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Authors:  Catherine E Calkins
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3.  Splenic but not thymic autoreactive T cells from New Zealand Black mice respond to a dominant erythrocyte Band 3 peptide.

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Journal:  Immunology       Date:  1999-04       Impact factor: 7.397

4.  Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia.

Authors:  Andrew M Hall; Omar M Zamzami; Natasha Whibley; Daniel P Hampsey; Anne M Haggart; Mark A Vickers; Robert N Barker
Journal:  Haematologica       Date:  2012-03-14       Impact factor: 9.941

5.  Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea.

Authors:  Geraldo Gs Oliveira; John Holton; Peter M Lydyard
Journal:  Gut Microbes       Date:  2010-05-24

6.  T-helper 1 dominated responses to erythrocyte Band 3 in NZB mice.

Authors:  C R Shen; G Mazza; F E Perry; J T Beech; S J Thompson; A Corato; S Newton; R N Barker; C J Elson
Journal:  Immunology       Date:  1996-10       Impact factor: 7.397

7.  T-cell specificity in murine autoimmune haemolytic anaemia induced by rat red blood cells.

Authors:  R N Barker; C-R Shen; C J Elson
Journal:  Clin Exp Immunol       Date:  2002-08       Impact factor: 4.330

8.  Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice.

Authors:  Abdel-Rahman Youssef; Christopher J Elson
Journal:  Auto Immun Highlights       Date:  2017-04-28
  8 in total

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