Literature DB >> 6404263

Adriamycin and daunomycin induce interstrand DNA crosslinks in Hela S3 Cells.

J Konopa.   

Abstract

By using a new mild procedure for detecting DNA crosslinks it has been shown that adriamycin and daunomycin are able to form interstrand DNA crosslinks in HeLa cells. This effect seems to be preceded by transformation of the parent antibiotics in the cell to active forms. In addition, interstrand DNA crosslinks formed by adriamycin and daunomycin were found to be temperature- and alkali-labile.

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Year:  1983        PMID： 6404263     DOI： 10.1016/0006-291x(83)91035-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Stability of adriamycin-induced DNA adducts and interstrand crosslinks.

Authors:  A van Rosmalen; C Cullinane; S M Cutts; D R Phillips
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

2.  Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival factors for MDA-231 cells exposed to adriamycin.

Authors:  A Geier; R Beery; M Haimsohn; R Hemi; Z Malik; A Karasik
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-12       Impact factor: 2.416

3.  Use of oligonucleotides to define the site of interstrand cross-links induced by Adriamycin.

Authors:  S M Cutts; D R Phillips
Journal:  Nucleic Acids Res       Date:  1995-07-11       Impact factor: 16.971

4.  Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells.

Authors:  A Skladanowski; J Konopa
Journal:  Br J Cancer       Date:  2000-04       Impact factor: 7.640

5.  Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations.

Authors:  Kate E Coldwell; Suzanne M Cutts; Ted J Ognibene; Paul T Henderson; Don R Phillips
Journal:  Nucleic Acids Res       Date:  2008-07-16       Impact factor: 16.971

6.  Variants deficient in phagocytosis of latex beads isolated from the murine macrophagelike cell line J774.

Authors:  S Takasaki; F Emling; L Leive
Journal:  J Cell Biol       Date:  1984-06       Impact factor: 10.539

7.  Mutagenic and cytotoxic activity of doxorubicin and daunorubicin derivatives on prokaryotic and eukaryotic cells.

Authors:  N Babudri; B Pani; M Tamaro; C Monti-Bragadin; F Zunino
Journal:  Br J Cancer       Date:  1984-07       Impact factor: 7.640
  7 in total

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