Literature DB >> 10755405

Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells.

A Skladanowski1, J Konopa.   

Abstract

We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S3 cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA cross-linking is associated with the cytotoxic and anti-tumour activity of these compounds.

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Year:  2000        PMID： 10755405      PMCID： PMC2374491          DOI： 10.1054/bjoc.1999.1095

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

1.  Dissociation of cytotoxicity and DNA cleavage activity induced by topoisomerase II-reactive intercalating agents in hamster-human somatic cell hybrids.

Authors:  B S Glisson; A M Killary; P Merta; W E Ross; J Siciliano; M J Siciliano
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 2.  Biochemical pharmacology of anthracenediones and anthrapyrazoles.

Authors:  D W Fry
Journal:  Pharmacol Ther       Date:  1991-10       Impact factor: 12.310

3.  8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity.

Authors:  W M Cholody; S Martelli; J Konopa
Journal:  J Med Chem       Date:  1990-10       Impact factor: 7.446

4.  Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.

Authors:  P J Smith; S A Morgan; M E Fox; J V Watson
Journal:  Biochem Pharmacol       Date:  1990-11-01       Impact factor: 5.858

5.  DNA strand breakage by peroxidase-activated mitoxantrone.

Authors:  G R Fisher; L H Patterson
Journal:  J Pharm Pharmacol       Date:  1991-01       Impact factor: 3.765

Review 6.  Pharmacokinetics and metabolism of mitoxantrone. A review.

Authors:  G Ehninger; U Schuler; B Proksch; K P Zeller; J Blanz
Journal:  Clin Pharmacokinet       Date:  1990-05       Impact factor: 6.447

7.  Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug.

Authors:  K Reszka; J A Hartley; P Kolodziejczyk; J W Lown
Journal:  Biochem Pharmacol       Date:  1989-12-01       Impact factor: 5.858

8.  5-[(Aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic agents. Synthesis and biological activity.

Authors:  W M Cholody; S Martelli; J Paradziej-Lukowicz; J Konopa
Journal:  J Med Chem       Date:  1990-01       Impact factor: 7.446

9.  32P-postlabelling analysis of adducts formed by mitoxantrone and ametantrone with DNA and homopolydeoxyribonucleotides after enzymatic activation.

Authors:  P Dackiewicz; A Skladanowski; J Konopa
Journal:  Chem Biol Interact       Date:  1995-11-17       Impact factor: 5.192

10.  Adriamycin and daunomycin induce interstrand DNA crosslinks in Hela S3 Cells.

Authors:  J Konopa
Journal:  Biochem Biophys Res Commun       Date:  1983-02-10       Impact factor: 3.575
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  2 in total

1.  Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies.

Authors:  Marcin Koba; Tomasz Bączek
Journal:  Med Chem Res       Date:  2010-11-17       Impact factor: 1.965

2.  Transcriptome analysis of differentially expressed genes and pathways associated with mitoxantrone treatment prostate cancer.

Authors:  Sanqiang Li; Ruifang Li; Yu Ma; Cong Zhang; Tao Huang; Sha Zhu
Journal:  J Cell Mol Med       Date:  2018-12-27       Impact factor: 5.310
  2 in total

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