Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3.

Literature DB >> 6403648

The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3.

Abstract

Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa-5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6403648 PMCID： PMC2186950 DOI： 10.1084/jem.157.3.1070

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

19 in total

1. Cytotoxic Thy 1,2-positive blasts with NK-like target selectivity in murine mixed lymphocyte cultures.

Authors: K Kärre; J K Seeley
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

Review 2. Morphological and functional characterization of isolated effector cells responsible for human natural killer activity to fetal fibroblasts and to cultured cell line targets.

Authors: E Saksela; T Timonen; A Ranki; P Häyry
Journal: Immunol Rev Date: 1979 Impact factor: 12.988

3. Natural cytotoxic cells against solid tumors in mice. II. Some characteristics of the effector cells.

Authors: C J Paige; E F Figarella; M J Cuttito; A Cahan; O Stutman
Journal: J Immunol Date: 1978-11 Impact factor: 5.422

Review 4. Natural cell-mediated immunity.

Authors: R B Herberman; H T Holden
Journal: Adv Cancer Res Date: 1978 Impact factor: 6.242

5. T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors: S Gillis; M M Ferm; W Ou; K A Smith
Journal: J Immunol Date: 1978-06 Impact factor: 5.422

6. Natural cytotoxic cells against solid tumors in mice. I. Strain and age distribution and target cell susceptibility.

Authors: O Stutman; C J Paige; E F Figarella
Journal: J Immunol Date: 1978-11 Impact factor: 5.422

7. Augmentation of mouse natural killer cell activity by interferon and interferon inducers.

Authors: J Y Djeu; J A Heinbaugh; H T Holden; R B Herberman
Journal: J Immunol Date: 1979-01 Impact factor: 5.422

8. Natural cytotoxic cells against solid tumors in mice: blocking of cytotoxicity by D-mannose.

Authors: O Stutman; P Dien; R E Wisun; E C Lattime
Journal: Proc Natl Acad Sci U S A Date: 1980-05 Impact factor: 11.205

9. Normal levels of natural cytotoxic cells against solid tumours in NK-deficient beige mice.

Authors: O Stutman; M J Cuttito
Journal: Nature Date: 1981-03-19 Impact factor: 49.962

10. Tumor necrosis serum induces a serologically distinct population of NK cells.

Authors: M Chun; V Pasanen; U Hämmerling; G F Hämmerling; M K Hoffmann
Journal: J Exp Med Date: 1979-09-19 Impact factor: 14.307

18 in total

1. Antitumor immune surveillance by tumor necrosis factor producing cells.

Authors: E C Lattime; O Stutman
Journal: Immunol Res Date: 1991 Impact factor: 2.829

2. Immunoregulatory dysfunctions in type I diabetes: natural and antibody-dependent cellular cytotoxic activities.

Authors: M P Nair; E W Lewis; S A Schwartz
Journal: J Clin Immunol Date: 1986-09 Impact factor: 8.317

3. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.

Authors: A H Schinkel; U Mayer; E Wagenaar; C A Mol; L van Deemter; J J Smit; M A van der Valk; A C Voordouw; H Spits; O van Tellingen; J M Zijlmans; W E Fibbe; P Borst
Journal: Proc Natl Acad Sci U S A Date: 1997-04-15 Impact factor: 11.205

4. Natural cytotoxic (NC) activity: a multi-lineage system regulated by IL-2.

Authors: E C Lattime; M J Bykowsky; O Stutman
Journal: Immunol Res Date: 1986 Impact factor: 2.829

5. Increased lymphokine activated killer (LAK) activity in the regional lymph nodes of mice following immunization with contact sensitizing agents.

Authors: L Q Gao; G L Asherson; M Malkovsky
Journal: Clin Exp Immunol Date: 1987-10 Impact factor: 4.330

6. Heterogeneous cytotoxic cells that kill NC-sensitive WEHI-164 tumor cells are activated in allogeneic mixed lymphocyte reactions.

Authors: S Macphail; O Stutman
Journal: Immunol Res Date: 1986 Impact factor: 2.829

7. Origin and differentiation of natural killer cells. III. Relationship between the precursors and effectors of natural killer and natural cytotoxic activity.

Authors: J Hackett; M Bennett; G C Koo; V Kumar
Journal: Immunol Res Date: 1986 Impact factor: 2.829

8. Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6.

Authors: D Habetswallner; E Pelosi; D Bulgarini; A Camagna; P Samoggia; E Montesoro; G Giannella; D Lazzaro; G Isacchi; U Testa
Journal: Immunology Date: 1988-11 Impact factor: 7.397

9. Natural killer cell and islet killer cell activities in type 1 (insulin-dependent) diabetes.

Authors: K Negishi; N Waldeck; G Chandy; B Buckingham; A Kershnar; L Fisher; S Gupta; M A Charles
Journal: Diabetologia Date: 1986-06 Impact factor: 10.122

10. Contrasting effects of RNA and protein synthesis blocking on natural and lectin-dependent cell-mediated cytotoxicity against adherent HEp-2 cells.

Authors: A Perl; R Gonzalez-Cabello; L Falucskai; P Gergely; J Fehér
Journal: Experientia Date: 1985-10-15