Literature DB >> 6401508

Low serum testosterone concentrations in patients with carcinoma of the pancreas.

B Greenway, M J Iqbal, P J Johnson, R Williams.   

Abstract

The detection of high activities of two sex-steroid biosynthetic enzymes-aromatase and 5-alpha-reductase-in pancreatic carcinoma tissue suggested the possibility that these enzymes may influence the circulating concentrations of sex-steroid hormones. Mean serum testosterone concentrations in 22 men and women with exocrine carcinoma of the pancreas were significantly lower than those in 20 healthy controls and 27 patients with other known malignancies, who were of similar age and sex composition. Low serum testosterone concentrations may be due to uptake by and metabolism within the tumour; alternatively, patients with low androgen concentrations may be at greater risk of developing pancreatic carcinoma.

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Year:  1983        PMID： 6401508      PMCID： PMC1546416          DOI： 10.1136/bmj.286.6359.93

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  8 in total

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Journal:  Lancet       Date:  1967-03-11       Impact factor: 79.321

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Journal:  Lancet       Date:  1971-08-21       Impact factor: 79.321

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Authors:  A Vermeulen; R Rubens; L Verdonck
Journal:  J Clin Endocrinol Metab       Date:  1972-04       Impact factor: 5.958

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Authors:  W R Miller; R A Hawkins; A P Forrest
Journal:  Eur J Cancer Clin Oncol       Date:  1981-08

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Authors:  B Greenway; M J Iqbal; P J Johnson; R Williams
Journal:  Br Med J (Clin Res Ed)       Date:  1981-09-19

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Authors:  B Greenway; D Duke; B Pym; M J Iqbal; P J Johnson; R Williams
Journal:  Br J Surg       Date:  1982-10       Impact factor: 6.939

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Journal:  Br J Cancer       Date:  1974-12       Impact factor: 7.640
  8 in total
  13 in total

Review 1.  Chemoprevention for pancreatic cancer.

Authors:  Robert A Wolff
Journal:  Int J Gastrointest Cancer       Date:  2003

2.  Luteinizing hormone pulsatility and computer-assisted analysis of sperm features in patients with Hodgkin's disease.

Authors:  M Magnanti; S Malizia; G Garufi; A Lenzi; A P Anselmo; F Beligotti; A Fabbrini; V Santiemma
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

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Authors:  Z Tulassay; Z Sándor; L Bodrogi; J Papp; T Fehér
Journal:  BMJ       Date:  1988-12-03

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Authors:  A Andrén-Sandberg; J Johansson
Journal:  Int J Pancreatol       Date:  1990 Aug-Nov

5.  Androgen receptor-blocking agents: potential role in pancreatic cancer.

Authors:  B A Greenway
Journal:  Drugs Aging       Date:  2000-09       Impact factor: 3.923

6.  Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma.

Authors:  K N Syrigos; I Fyssas; M M Konstandoulakis; K J Harrington; S Papadopoulos; N Milingos; P Peveretos; B C Golematis
Journal:  Gut       Date:  1998-01       Impact factor: 23.059

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Authors:  T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

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Authors:  M Meijers; C J Visser; J G Klijn; S W Lamberts; A van Garderen-Hoetmer; F H de Jong; J A Foekens; R A Woutersen
Journal:  Int J Pancreatol       Date:  1992-04

Review 9.  Biology of pancreatic cancer.

Authors:  G J Poston; J Gillespie; P J Guillou
Journal:  Gut       Date:  1991-07       Impact factor: 23.059

10.  Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo controlled trial.

Authors:  B A Greenway
Journal:  BMJ       Date:  1998-06-27
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