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Literature DB >> 6401117

Possible molecular detent in the DNA structure at regulatory sequences.

Abstract

A common feature that appears in a number of DNA sites where proteins interact is the sequence GTG/CAC. In the lac operator this sequence leads to a region with a higher imino proton exchange rate well below the optical melting temperature. It is suggested that this reflects a structural feature recognized by proteins that bind specific sites on the DNA molecule.

Mesh：

Substances：
Repressor Proteins
DNA

Year: 1983 PMID： 6401117 DOI： 10.1080/07391102.1983.10507458

Source DB: PubMed Journal: J Biomol Struct Dyn ISSN： 0739-1102

Keyword Cloud
Cited

12 in total

1. Curved DNA without A-A: experimental estimation of all 16 DNA wedge angles.

Authors: A Bolshoy; P McNamara; R E Harrington; E N Trifonov
Journal: Proc Natl Acad Sci U S A Date: 1991-03-15 Impact factor: 11.205

2. NMR Studies of an SV40 Enhancer Core DNA Sequence.

Authors: M Donlan; S Cheung; P Lu
Journal: Biophys J Date: 1986-01 Impact factor: 4.033

3. Base-pair opening and spermine binding--B-DNA features displayed in the crystal structure of a gal operon fragment: implications for protein-DNA recognition.

Authors: L W Tari; A S Secco
Journal: Nucleic Acids Res Date: 1995-06-11 Impact factor: 16.971

4. Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

Authors: R M Schaaper
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

5. Conserved elements in the transcription initiation regions preceding highly expressed structural genes of methanogenic archaebacteria.

Authors: R Allmansberger; S Knaub; A Klein
Journal: Nucleic Acids Res Date: 1988-08-11 Impact factor: 16.971

6. Partial overlapping of binding sequences for steroid hormone receptors and DNaseI hypersensitive sites in the rabbit uteroglobin gene region.

Authors: K Jantzen; H P Fritton; T Igo-Kemenes; E Espel; S Janich; A C Cato; K Mugele; M Beato
Journal: Nucleic Acids Res Date: 1987-06-11 Impact factor: 16.971

Possible molecular detent in the DNA structure at regulatory sequences.

1. Curved DNA without A-A: experimental estimation of all 16 DNA wedge angles.

2. NMR Studies of an SV40 Enhancer Core DNA Sequence.

3. Base-pair opening and spermine binding--B-DNA features displayed in the crystal structure of a gal operon fragment: implications for protein-DNA recognition.

4. Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

5. Conserved elements in the transcription initiation regions preceding highly expressed structural genes of methanogenic archaebacteria.

6. Partial overlapping of binding sequences for steroid hormone receptors and DNaseI hypersensitive sites in the rabbit uteroglobin gene region.

7. A common structural feature in promoter sequences of E. coli.

8. Sequence signals which may be required for efficient formation of mRNA 3' termini.

9. Structural wrinkles and the genomic regulatory sites of eukaryotes.

10. Correlation of lac operator DNA imino proton exchange kinetics with its function.