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Literature DB >> 639836

Metabolism of phenazone in man after hydrocortisone administration.

Abstract

The influence of a high plasma concentration of hydrocortisone on the metabolism of phenazone in humans has been studied. Two series of experiments were carried out, Group A to demonstrate any enzyme-inducing effect of hydrocortisone, and Group B to study the immediate effect of hydrocortisone on the metabolism of phenazone. 9 subjects (Group A) received a total 250--400 mg hydrocortisone i.m. twice daily for three days and the 24-hour elimination of phenazone was studied before and afterwards. In a further 5 subjects (Group B) the elimination of phenazone was examined during administration of hydrocortisone of placebo. The elimination rate and the apparent volume of distribution of phenazone remained unchanged under both experimental conditions.

Entities: Chemical Species

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Year: 1978 PMID： 639836 DOI： 10.1007/BF00606685

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

16 in total

Review 1. Enzyme induction (first of three parts).

Authors: T D Gelehrter
Journal: N Engl J Med Date: 1976-03-04 Impact factor: 91.245

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Authors: H REMMER
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1958

3. Cortical and medullary adrenal activity in surgical and allied conditions.

Authors: C FRANKSSON; C A GEMZELL; U S VON EULER
Journal: J Clin Endocrinol Metab Date: 1954-06 Impact factor: 5.958

4. Effect of pregnancy or treatment with cetain steroids on N,N-dimethylaniline demethylation and N-oxidation by rabbit liver or lung microsomes.

Authors: T R Devereux; J R Fouts
Journal: Drug Metab Dispos Date: 1975 Jul-Aug Impact factor: 3.922

Review 5. The endocrine response to trauma.

Authors: I D Johnston
Journal: Adv Clin Chem Date: 1972 Impact factor: 5.394

6. Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.

Authors: J A Castro; F E Greene; P Gigon; H Sasame; J R Gillette
Journal: Biochem Pharmacol Date: 1970-08 Impact factor: 5.858

7. Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers.

Authors: S Lindgren; P Collste; B Norlander; F Sjöqvist
Journal: Eur J Clin Pharmacol Date: 1974-08-23 Impact factor: 2.953

8. Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.

Authors: T R Tephly; G J Mannering
Journal: Mol Pharmacol Date: 1968-01 Impact factor: 4.436

9. The inhibitory effect of hydrocortisone and testosterone on the plasma disappearance of nortriptyline in the dog and the perfused rat liver.

Authors: C von Bahr; F Sjöqvist; S Orrenius
Journal: Eur J Pharmacol Date: 1970-01 Impact factor: 4.432

Metabolism of phenazone in man after hydrocortisone administration.

Review 1. Enzyme induction (first of three parts).

2. [Acceleration of evipan degradation by glycocorticoids].

3. Cortical and medullary adrenal activity in surgical and allied conditions.

4. Effect of pregnancy or treatment with cetain steroids on N,N-dimethylaniline demethylation and N-oxidation by rabbit liver or lung microsomes.

Review 5. The endocrine response to trauma.

6. Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.

7. Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers.

8. Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.

9. The inhibitory effect of hydrocortisone and testosterone on the plasma disappearance of nortriptyline in the dog and the perfused rat liver.

10. Corticosteroid treatment and surgery. 1. An investigation of the indications for steroid cover.

1. Effect of prednisolone on theophylline pharmacokinetics in patients with chronic airflow obstruction.

Review 2. Drug pharmacokinetics in the postoperative period.

3. Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease.

4. Effect of short surgical procedures on salivary paracetamol elimination.

5. Effect of halothane anaesthesia on salivary elimination of paracetamol.

6. Changes in serum levels of quinolones in rats under the influence of experimental trauma.