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Literature DB >> 4041337

Effect of short surgical procedures on salivary paracetamol elimination.

K Ray, C Adithan, J S Bapna, P R Kangle, K Ray, S Ramakrishnan.

Abstract

The effect of short surgical procedures on paracetamol elimination was studied in seven male patients undergoing surgery with epidural anaesthesia. Five healthy volunteers who did not undergo surgery served as a control group. Paracetamol concentration was measured in saliva at various intervals 1 day before and after surgery. Paracetamol half-life (t1/2,z) decreased and metabolic clearance rate (CL) increased after surgery as compared to preoperative values. The results suggest that surgical stress may enhance the hepatic metabolism of paracetamol.

Entities: Chemical Species

Mesh：

Substances：
Acetaminophen

Year: 1985 PMID： 4041337 PMCID： PMC1400672 DOI： 10.1111/j.1365-2125.1985.tb05054.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

14 in total

Review 1. The endocrine response to trauma.

Authors: I D Johnston
Journal: Adv Clin Chem Date: 1972 Impact factor: 5.394

3. Pharmacokinetic consequences and toxicologic implications of metyrapone-induced alterations of acetaminophen elimination in man.

Authors: R E Galinsky; E B Nelson; D E Rollins
Journal: Eur J Clin Pharmacol Date: 1987 Impact factor: 2.953

3 in total

Effect of short surgical procedures on salivary paracetamol elimination.

Review 1. The endocrine response to trauma.

2. Immediate decrease by hydrocortisone of the plasma half-life of antipyrine.

3. Effects of physical stress on the disposition of drugs eliminated by the liver in man.

4. Acetaminophen metabolism in man, as determined by high-resolution liquid chromatography.

5. Effects of heat and exercise on the elimination of pralidoxime in man.

6. Drug therapy. Acetaminophen.

7. Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration.

8. A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man.

9. Failure of hydrocortisone to alter acutely antipyrine disposition.

10. Metabolism of phenazone in man after hydrocortisone administration.

1. A comparison of serum and saliva paracetamol concentrations.

2. Effect of halothane anaesthesia on salivary elimination of paracetamol.

3. Pharmacokinetic consequences and toxicologic implications of metyrapone-induced alterations of acetaminophen elimination in man.