Literature DB >> 6397024

Effect of age on Agaricus bisporus PHA-B stimulated insulin release and 45Ca2+ uptake in vitro by islets of Langerhans.

N Ahmad, M M Khan, A K Rastogi, J R Kidwai.   

Abstract

The in vitro basal insulin release and 45Ca2+ uptake by rat islets of Langerhans remain unaffected by the animal's age. However, when Agaricus bisporus lectin PHA-B is added to the medium, there is a significant stimulation of basal insulin secretion and 45Ca2+ uptake. The islets isolated from younger rats are more sensitive to A. bisporus PHA-B stimulation and register 1.5-fold and 3-fold more increases of insulin release and 45Ca2+ uptake respectively as compared to islets isolated from 12-month-old rats. Age-related conformational changes in the B-cell membrane are suggested as a possible explanation for the above observation.

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Year:  1984        PMID： 6397024     DOI： 10.1007/BF02582088

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  24 in total

1.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

2.  The relation between age and the B/A cell ratio in the islet tissue of the rat.

Authors:  B HELLMAN
Journal:  Acta Endocrinol (Copenh)       Date:  1959-05

3.  Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors:  P E Lacy; M Kostianovsky
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461

4.  Amounts and distribution of intracellular magnesium and calcium in pancreatic beta-cells.

Authors:  T Andersson; P O Berggren; E Gylfe; B Hellman
Journal:  Acta Physiol Scand       Date:  1982-02

5.  A possible role for insulin in the altered capability for hepatic enzyme adaptation during aging.

Authors:  G Gold; K Karoly; C Freeman; R C Adelman
Journal:  Biochem Biophys Res Commun       Date:  1976-12-20       Impact factor: 3.575

6.  Effect of PHA-B fraction of Agaricus bisporus lectin on insulin release and 45Ca2+ uptake by islets of Langerhans in vitro.

Authors:  N Ahmad; R Bansal; A K Rastogi; J R Kidwai
Journal:  Acta Diabetol Lat       Date:  1984 Jan-Mar

7.  Effect of age on glucose-stimulated insulin release by the beta-cell of the rat.

Authors:  E P Reaven; G Gold; G M Reaven
Journal:  J Clin Invest       Date:  1979-08       Impact factor: 14.808

8.  Effects of glucose on 45Ca2+ uptake by pancreatic islets as studied with the lanthanum method.

Authors:  B Hellman; J Sehlin; I B Täljedal
Journal:  J Physiol       Date:  1976-01       Impact factor: 5.182

9.  Oral glucose tolerance and related factors in a normal population sample. I. Blood sugar, plasma insulin, glyceride, and cholesterol measurements and the effects of age and sex.

Authors:  D R Boyns; J N Crossley; M E Abrams; R J Jarrett; H Keen
Journal:  Br Med J       Date:  1969-03-08

10.  The effect of glucose stimulation on 45calcium uptake of rat pancreatic islets and their total calcium content as measured by a fluorometric micro-method.

Authors:  G H Wolters; J B Wiegman; W Konijnendijk
Journal:  Diabetologia       Date:  1982-02       Impact factor: 10.122
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  2 in total

1.  Effect of age on the binding of lectin 125I-PHA-B to pancreatic islets of rat in vitro and stimulation of some cellular events.

Authors:  P Khalid; F Ahmad; M M Khan; A K Rastogi; J R Kidwai
Journal:  Acta Diabetol Lat       Date:  1989 Apr-Jun

Review 2.  Mushrooms as Potential Sources of Active Metabolites and Medicines.

Authors:  Anne Bhambri; Malay Srivastava; Vivek G Mahale; Sushma Mahale; Santosh Kumar Karn
Journal:  Front Microbiol       Date:  2022-04-26       Impact factor: 6.064
  2 in total

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