Literature DB >> 6394600

Cystatin S: a cysteine proteinase inhibitor of human saliva.

S Isemura, E Saitoh, S Ito, M Isemura, K Sanada.   

Abstract

An acidic protein of human saliva, which we named SAP-1 previously, is now shown to be an inhibitor of several cysteine proteinases. The protein inhibited papain and ficin strongly, and stem bromelain and bovine cathepsin C partially. However, it did not inhibit either porcine cathepsin B or clostripain. The mode of the inhibition of papain was found to be non-competitive. The name cystatin S has been proposed for this salivary protein in view of the similarities in activity and structure to other cysteine proteinase inhibitors such as chicken egg-white cystatin and human cystatins A, B, and C. The cystatin S antigen was detected immunohistochemically in the serous cells of human parotid and submaxillary glands.

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Year:  1984        PMID： 6394600     DOI： 10.1093/oxfordjournals.jbchem.a134952

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  13 in total

1.  Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva.

Authors:  N Ramasubbu; M S Reddy; E J Bergey; G G Haraszthy; S D Soni; M J Levine
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

2.  Potential biomarkers of human salivary function: a modified proteomic approach.

Authors:  J D Rudney; R K Staikov; J D Johnson
Journal:  Arch Oral Biol       Date:  2008-09-18       Impact factor: 2.633

3.  Genetic polymorphisms of the CST2 locus coding for cystatin SA.

Authors:  M Shintani; K Minaguchi; S Isemura; E Saitoh; K Sanada; T Semba
Journal:  Hum Genet       Date:  1994-07       Impact factor: 4.132

4.  Immunocytochemical localization of seminal proteins in salivary and lacrimal glands of the rat.

Authors:  G Aumüller; E A Arce; W Heyns; I Vercaeren; I Dammshäuser; J Seitz
Journal:  Cell Tissue Res       Date:  1995-04       Impact factor: 5.249

5.  Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases.

Authors:  G Salvesen; C Parkes; M Abrahamson; A Grubb; A J Barrett
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857

6.  Identification of cysteine proteases and screening of cysteine protease inhibitors in biological samples by a two-dimensional gel system of zymography and reverse zymography.

Authors:  Eiichi Saitoh; Shinya Yamamoto; Eishiro Okamoto; Yoshimi Hayakawa; Takashi Hoshino; Ritsuko Sato; Satoko Isemura; Sadami Ohtsubo; Masayuki Taniguchi
Journal:  Anal Chem Insights       Date:  2007-11-18

7.  Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).

Authors:  J Ghiso; O Jensson; B Frangione
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

8.  Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry.

Authors:  L A Bobek; A Aguirre; M J Levine
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

9.  Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis.

Authors:  Sompop Bencharit; Sarah Schwartz Baxter; Jim Carlson; Warren C Byrd; Mary Virginia Mayo; Michael B Border; Heidi Kohltfarber; Eugene Urrutia; Escher L Howard-Williams; Steven Offenbacher; Michael C Wu; John B Buse
Journal:  Mol Biosyst       Date:  2013-11

10.  Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility.

Authors:  Mariana Camargo; Emad Ibrahim; Teodoro C Aballa; Karina H M Cardozo; Valdemir M Carvalho; Charles M Lynne; Nancy L Brackett; Ricardo P Bertolla
Journal:  J Spinal Cord Med       Date:  2020-02-11       Impact factor: 1.985
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