Literature DB >> 6388924

Non-immune IgG binding to the surface of spermatozoa by disulphide rearrangement.

J M Richards, S S Witkin.   

Abstract

The mechanism whereby immunoglobulin binds to the surface of spermatozoa was investigated. IgG reacts with spermatozoa non-specifically via the Fc portion of the molecule, while both IgM and IgA are completely unreactive. This selective binding of IgG is non-competitive, resistant to heat, proteases and non-ionic detergents and is not mediated by an Fc receptor on the sperm surface. Instead, evidence is presented that IgG covalently binds to spermatozoa by an exchange reaction between labile disulphides on both the sperm surface and IgG-Fc. It is calculated that there are 3 X 10(11) exchangeable disulphide bonds per bull spermatozoon.

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Year:  1984        PMID： 6388924      PMCID： PMC1577050     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  25 in total

1.  Extensive disulfide bonding at the mammalian cell surface.

Authors:  R O Hynes; A Destree
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

2.  Receptors for immunoglobulin Fc in human malignant tissues.

Authors:  O Tonder; S Thunold
Journal:  Scand J Immunol       Date:  1973       Impact factor: 3.487

3.  Studies on the immunoglobulins which stimulate the ingestion of glutaraldehyde-treated red cells attached to macrophages.

Authors:  M Rabinovitch
Journal:  J Immunol       Date:  1967-12       Impact factor: 5.422

4.  Ultrastructural changes in the hamster sperm head during fertilization.

Authors:  R Yanagimachi; Y D Noda
Journal:  J Ultrastruct Res       Date:  1970-06

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Studies of 125I trace labeling of immunoglobulin G by chloramine-T.

Authors:  S Sonoda; M Schlamowitz
Journal:  Immunochemistry       Date:  1970-11

Review 7.  Lymphocyte receptors for immunoglobulin.

Authors:  H B Dickler
Journal:  Adv Immunol       Date:  1976       Impact factor: 3.543

8.  The occurrence and possible functional significance of -S-S- crosslinks in sperm heads, with particular reference to eutherian mammals.

Authors:  J M Bedford; H I Calvin
Journal:  J Exp Zool       Date:  1974-05

9.  Changes in -S-S- linked structures of the sperm tail during epididymal maturation, with comparative observations in sub-mammalian species.

Authors:  J M Bedford; H I Calvin
Journal:  J Exp Zool       Date:  1974-02

10.  Interaction of aggregated -globulin with B lymphocytes.

Authors:  H B Dickler; H G Kunkel
Journal:  J Exp Med       Date:  1972-07-01       Impact factor: 14.307
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  3 in total

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2.  E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling.

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Journal:  Development       Date:  2021-01-13       Impact factor: 6.868

3.  Non-specific binding of antibodies in immunohistochemistry: fallacies and facts.

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Journal:  Sci Rep       Date:  2011-07-01       Impact factor: 4.379
  3 in total

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