Literature DB >> 6386023

Effect of indapamide on the renin-aldosterone system, and urinary excretion of potassium and calcium in essential hypertension.

H Danielsen, E B Pedersen, E S Spencer.   

Abstract

The effect of indapamide, 2.5 mg daily, on blood pressure, electrolyte balance and the renin-aldosterone system was studied in 11 patients with essential hypertension. During indapamide treatment blood pressure decreased and the renin-aldosterone system was stimulated. A moderate hypokalaemia seen during indapamide treatment was not correlated to changes in plasma aldosterone concentration. Fractional excretion of potassium was unchanged during treatment, while renal calcium excretion was reduced. No effect on calcium in serum was observed.

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Year:  1984        PMID： 6386023      PMCID： PMC1463508          DOI： 10.1111/j.1365-2125.1984.tb02458.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  6 in total

1.  Plasma renin concentration measured by use of radioimmunoassay for angiotensin I.

Authors:  J Giese; M Jörgensen; M D Nielsen; J O Lund; O Munck
Journal:  Scand J Clin Lab Invest       Date:  1970-12       Impact factor: 1.713

2.  The effect of indomethacin on plasma renin activity in man under normal conditions and after stimulation of the renin angiotensin system.

Authors:  K W Rumpf; S Frenzel; H D Lowitz; F Scheler
Journal:  Prostaglandins       Date:  1975-10

3.  Antihypertensive effect of indapamide with special emphasis on renal prostaglandin production.

Authors:  M LeBel; J H Grose; L J Belleau; S Langlois
Journal:  Curr Med Res Opin       Date:  1983       Impact factor: 2.580

Review 4.  Prevention of calcium stones with thiazides.

Authors:  E R Yendt; M Cohanim
Journal:  Kidney Int       Date:  1978-05       Impact factor: 10.612

5.  changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms.

Authors:  A S Brickman; S G Massry; J W Coburn
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

6.  The significance of bile acids and aldosterone for the electrical hyperpolarization of human rectum in obese patients treated with intestinal bypass operation.

Authors:  J Rask-Madsen; A Bruusgaard; O Munck; M D Nielsen; H Worning
Journal:  Scand J Gastroenterol       Date:  1974       Impact factor: 2.423
  6 in total
  2 in total

1.  Comparison of indapamide and hydrochlorothiazide plus amiloride as a third drug in the treatment of arterial hypertension.

Authors:  L Poulsen; M Friberg; I Noer; L Krusell; O L Pedersen
Journal:  Cardiovasc Drugs Ther       Date:  1989-04       Impact factor: 3.727

2.  Fracture risk and the use of a diuretic (indapamide SR) +/- perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET).

Authors:  Christopher J Bulpitt; Ruth Peters; Jan A Staessen; Lutgarde Thijs; Marie-Christine De Vernejoul; Astrid E Fletcher; Nigel S Beckett
Journal:  Trials       Date:  2006-12-19       Impact factor: 2.279
  2 in total

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