Literature DB >> 638315

Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats.

R E Buckingham, T C Hamilton, D Robson.   

Abstract

In DOCA-saline hypertensive rats, pindolol (4, 20 or 50 mg/kg orally) produced a hypotensive effect which was inversely related to dose. Following adrenal demedullation, a hypotensive response to the highest dose of pindolol was unmasked and the magnitude of the responses to lower doses was increased. The results suggest that adrenal catecholamines moderate the hypotensive effects of high doses of pindolol.

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Year:  1978        PMID： 638315      PMCID： PMC1668179          DOI： 10.1111/j.1476-5381.1978.tb08469.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Indwelling catheters for direct recording of arterial blood pressure and intravenous injection of drugs in the conscious rat.

Authors:  R E Buckingham
Journal:  J Pharm Pharmacol       Date:  1976-05       Impact factor: 3.765

2.  Letter: Paradoxical effect of pindolol.

Authors:  H J Waal-Manning; F O Simpson
Journal:  Br Med J       Date:  1975-07-19

3.  [Significance of adrenal catecholamines for reflex cardiovascular counterregulation in rats with renal hypertension].

Authors:  H Brunner; P R Hedwall
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1970

4.  The disposition of propranolol. II. Hepatic elimination in the rat.

Authors:  D G Shand; R E Rangno; G H Evans
Journal:  Pharmacology       Date:  1972       Impact factor: 2.547

5.  Studies on the cardiovascular effects of pindolol in DOCA/saline hypertensive rats.

Authors:  R E Buckingham; T C Hamilton; D Robson
Journal:  Br J Pharmacol       Date:  1977-07       Impact factor: 8.739

6.  A method for the fluorimetric determination of 4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB46), a beta-blocking agent, in plasma and urine.

Authors:  W L Pacha
Journal:  Experientia       Date:  1969-08-15

7.  Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol.

Authors:  R S Grewal; C L Kaul
Journal:  Br J Pharmacol       Date:  1970-04       Impact factor: 8.739
  7 in total
  3 in total

1.  Comparison of the effects of propranolol, pindolol, oxprenolol and acebutolol on atrioventricular conduction in unanaesthetized dogs.

Authors:  J P Kantelip; P Duchene-Marullaz; R Delaigue-Fabry; A Eschalier
Journal:  Br J Clin Pharmacol       Date:  1982       Impact factor: 4.335

2.  Comparison of the anti-hypertensive response to beta-adrenoceptor blocking drugs in intact and adrenal-demedullated spontaneously hypertensive rats.

Authors:  R E Buckingham; T C Hamilton
Journal:  Br J Pharmacol       Date:  1980-04       Impact factor: 8.739

3.  Contrasts between pindolol and propranolol concentration-response relationships.

Authors:  S G Carruthers; W L Pacha; W H Aellig
Journal:  Br J Clin Pharmacol       Date:  1985-10       Impact factor: 4.335
  3 in total

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