Literature DB >> 5441789

Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol.

R S Grewal, C L Kaul.   

Abstract

1. Propranolol antagonizes the hypotensive effect of guanethidine in renal hypertensive but not in adrenal demedullated renal hypertensive rats.2. Guanethidine does not interfere with the release of catecholamines from the adrenal gland which follows splanchnic nerve stimulation in cats anaesthetized with pentobarbitone.3. Guanethidine does not release or interfere with the release of catecholamines after the intravenous injection of physostigmine in the rat.4. Propranolol antagonizes the antihypertensive effect of guanethidine by potentiating the vasopressor effects of catecholamines released from the adrenal glands during the induction stage of ether anaesthesia.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 5441789      PMCID： PMC1702585          DOI： 10.1111/j.1476-5381.1970.tb09886.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Vasodilator action of guanethidine.

Authors:  F M ABBOUD; J W ECKSTEIN
Journal:  Circ Res       Date:  1962-11       Impact factor: 17.367

2.  Acute effects of guanethidine on myocardial contractility and catecholamine levels.

Authors:  J L BUTTERFIELD; J A RICHARDSON
Journal:  Proc Soc Exp Biol Med       Date:  1961-02

3.  The effects of guanethidine on the adrenal medulla.

Authors:  W J ATHOS; B P McHUGH; S E FINEBERG; J G HILTON
Journal:  J Pharmacol Exp Ther       Date:  1962-08       Impact factor: 4.030

4.  Influence of an adrenergic beta-receptor blocking agent on the effect of various hypotensive agents in the hypertensive rat.

Authors:  H Brunner; P R Hedwall; M Meier
Journal:  Experientia       Date:  1965-04-15

5.  Effect of physostigmine upon the output of catecholamines from the adrenal gland of the rat.

Authors:  C L Kaul; R S Grewal
Journal:  J Pharm Sci       Date:  1968-10       Impact factor: 3.534

6.  Adrenaline reversal by CIBA 1002-Go.

Authors:  R S Grewal; C L Kaul
Journal:  Eur J Pharmacol       Date:  1969-01       Impact factor: 4.432

7.  [2-Octahydro-1-azocinyl)-ethyl]-guanidine sulfate (CIBA 5864-SU), a new synthetic antithypertensive agents].

Authors:  R A MAXWELL; R P MULL; A J PLUMMER
Journal:  Experientia       Date:  1959-07-15

8.  Treatment of hypertension with propranolol.

Authors:  B N Prichard; P M Gillam
Journal:  Br Med J       Date:  1969-01-04

9.  Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent.

Authors:  R CASS; R KUNTZMAN; B B BRODIE
Journal:  Proc Soc Exp Biol Med       Date:  1960-04
  9 in total
  6 in total

1.  Depressor responses to spinal stimulation in the pithed rat.

Authors:  G J Dusting; M J Rand
Journal:  Br J Pharmacol       Date:  1972-06       Impact factor: 8.739

2.  Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats.

Authors:  R E Buckingham; T C Hamilton; D Robson
Journal:  Br J Pharmacol       Date:  1978-03       Impact factor: 8.739

Review 3.  Beta-adrenergic receptor blocking drugs in hypertension.

Authors:  F O Simpson
Journal:  Drugs       Date:  1974       Impact factor: 9.546

4.  Adrenalectomy abolishes antagonism of alpha-adrenoceptor-mediated hypotension by a beta-blocker in conscious rats.

Authors:  R Tabrizchi; C C Pang
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

5.  Importance of the sympathetic nervous system in the development of renal hypertension in the rat.

Authors:  R S Grewal; C L Kaul
Journal:  Br J Pharmacol       Date:  1971-08       Impact factor: 8.739

6.  Low voltage vagal nerve stimulation reduces bronchoconstriction in guinea pigs through catecholamine release.

Authors:  Thomas J Hoffmann; Bruce J Simon; Yi Zhang; Charles W Emala
Journal:  Neuromodulation       Date:  2012-05-02
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.