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Literature DB >> 638035

A morphological assessment of the stimulatory effect of coumarin on macrophages.

Abstract

In examining the migration of macrophages on to subcutaneously implanted coverslips in rats, it was found that coumarin (5-6 benzo-alpha-pyrone) and a preparation (Venalot) containing the former, very significantly increased the total macrophage number as well as the percentage of stimulation on the skin side of the coverslip. For the muscle side, Venalot increased the total numbers and the percentage stimulated while coumarin alone had no effect compared with the control. It remains to be seen whether these stimulated macrophages are also activated.

Entities: Chemical Species

Mesh：

Substances：
Coumarins

Year: 1978 PMID： 638035 PMCID： PMC2041321

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

9 in total

8. A comparison of the effect of benzopyrones and other drugs with anti-inflammatory properties on acid and neutral protease activity levels in various tissues after thermal injury.

Authors: N B Piller
Journal: Br J Exp Pathol Date: 1976-08

9. THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.

Authors: Z A COHN; B BENSON
Journal: J Exp Med Date: 1965-01-01 Impact factor: 14.307

9 in total

7 in total

6. Molecular docking and molecular dynamics simulation study of inositol phosphorylceramide synthase - inhibitor complex in leishmaniasis: Insight into the structure based drug design.

Authors: Vineetha Mandlik; Shailza Singh
Journal: F1000Res Date: 2016-07-08

7. Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents.

Authors: Vineetha Mandlik; Sohan Patil; Ramanamurthy Bopanna; Sudipta Basu; Shailza Singh
Journal: PLoS One Date: 2016-10-21 Impact factor: 3.240

7 in total

A morphological assessment of the stimulatory effect of coumarin on macrophages.

1. An in vitro demonstration of proteolysis by macrophages and its increase with coumarin.

2. Macrophage content of tumours in relation to metastatic spread and host immune reaction.

3. Macrophages in syngeneic animal tumours.

4. The value of multifactorial screening for anti-inflammatory activity as shown by coumarin.

5. [Effect of a Melilotus preparation on the activity of the reticuloendothelial system].

6. Macrophages and tumours.

7. Further evidence for the induction of proteolysis by coumarin in rats with various high-protein oedemas.

8. A comparison of the effect of benzopyrones and other drugs with anti-inflammatory properties on acid and neutral protease activity levels in various tissues after thermal injury.

9. THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.

1. Resolution rates of artificially produced protein and amino acid oedemas and the effects of a benzopyrone.

2. A comparison of coumarin and levamisole on parameters of the inflammatory response.

3. The effect of coumarin derivatives on the immunological system of man.

4. Coumarin or warfarin treatment of mice does not increase the microbicidal or tumoricidal capacities of macrophages.

5. Selective macrophage inhibition abolishes warfarin-induced reduction of metastasis.

6. Molecular docking and molecular dynamics simulation study of inositol phosphorylceramide synthase - inhibitor complex in leishmaniasis: Insight into the structure based drug design.

7. Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents.