Literature DB >> 6379146

Pharmacokinetic approach for reconstruction of predetermined plasma insulin profiles by continuous subcutaneous insulin infusion in depancreatized dogs.

H Hirayama, Y Kasuya, T Kobayashi, T Itoh, A Yagishita, T Katakura, K Isono.   

Abstract

A preprogrammable insulin delivery system which can provide the flexibility of varying plasma insulin concentration in a physiological manner has been developed. This system involves a program of continuous subcutaneous infusion of insulin at variable rates to reproduce arbitrarily selected plasma insulin concentration-time profiles. The desired insulin infusion rate profile was calculated from the desired insulin pattern using pharmacokinetic parameters experimentally determined by measurement of immunoreactive plasma insulin following a subcutaneous bolus dose to depancreatized dogs.

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Year:  1983        PMID： 6379146     DOI： 10.1007/bf01059059

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  19 in total

1.  Adipose tissue blood flow and insulin disappearance from subcutaneous tissue.

Authors:  K Kølendorf; J Bojsen; S L Nielsen
Journal:  Clin Pharmacol Ther       Date:  1979-05       Impact factor: 6.875

2.  The effect of aprotinin on the absorption of subcutaneously injected regular insulin in normal subjects.

Authors:  M Berger; H J Cüppers; P A Halban; R E Offord
Journal:  Diabetes       Date:  1980-01       Impact factor: 9.461

3.  The intravenous, intraperitoneal, and subcutaneous routes of insulin delivery in diabetic man.

Authors:  D S Schade; R P Eaton; N Friedman; W Spencer
Journal:  Diabetes       Date:  1979-12       Impact factor: 9.461

4.  Matched glucose responses to insulin administered subcutaneously and intravenously. Evidence for subcutaneous inactivation of insulin.

Authors:  R W Stevenson; T I Tsakok; J A Parsons
Journal:  Diabetologia       Date:  1980-05       Impact factor: 10.122

5.  Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site.

Authors:  M Berger; P A Halban; L Girardier; J Seydoux; R E Offord; A E Renold
Journal:  Diabetologia       Date:  1979-08       Impact factor: 10.122

6.  A glucose-controlled insulin infusion system for diabetic women during labour.

Authors:  M Nattrass; K G Alberti; K J Dennis; P N Gillibrand; A T Letchworth; A L Buckle
Journal:  Br Med J       Date:  1978-08-26

7.  Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump.

Authors:  W V Tamborlane; R S Sherwin; M Genel; P Felig
Journal:  N Engl J Med       Date:  1979-03-15       Impact factor: 91.245

8.  Long-term continuous intravenous insulin therapy with a portable insulin dosage-regulating apparatus.

Authors:  K Irsigler; H Kritz
Journal:  Diabetes       Date:  1979-03       Impact factor: 9.461

9.  Modeling of plasma disappearance of unlabeled insulin in man.

Authors:  K G Tranberg; H Dencker
Journal:  Am J Physiol       Date:  1978-12

10.  Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.

Authors:  J C Pickup; H Keen; J A Parsons; K G Alberti
Journal:  Br Med J       Date:  1978-01-28
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