Literature DB >> 488572

Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site.

M Berger, P A Halban, L Girardier, J Seydoux, R E Offord, A E Renold.   

Abstract

The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.

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Year:  1979        PMID： 488572     DOI： 10.1007/bf01222209

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  13 in total

1.  THE ROUTE OF INSULIN ADMINISTRATION IN THE MANAGEMENT OF DIABETES MELLITUS.

Authors:  J J NORA; D W SMITH; J R CAMERON
Journal:  J Pediatr       Date:  1964-04       Impact factor: 4.406

2.  Absorption of insulin-I-131 from subcutaneous tissue in diabetic patients.

Authors:  M C BALODIMOS; R H WILLIAMS
Journal:  Am J Med Sci       Date:  1962-01       Impact factor: 2.378

3.  Rate of clearance of insulin labelled with 131 I from the subcutaneous tissues in normal and diabetic subjects.

Authors:  C L JOINER
Journal:  Lancet       Date:  1959-05-09       Impact factor: 79.321

4.  The degradation of semisynthetic tritiated insulin by perfused mouse livers.

Authors:  P A Halban; C Karakash; J G Davies; R E Offord
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

5.  The preparation of a semisynthetic tritiated insulin with a specific radioactivity of up to 20 Curies per millimole.

Authors:  P A Halban; R E Offord
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

6.  Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat.

Authors:  M L Chandler; P T Varandani
Journal:  Biochim Biophys Acta       Date:  1972-11-24

7.  Absorption of injected insulin. A clinical-pharmacological study.

Authors:  C Binder
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1969

8.  Mobilization of subcutaneously injected tritiated insulin in rats: effects of muscular exercise.

Authors:  M Berger; P A Halban; W A Muller; R E Offord; A E Renold; M Vranic
Journal:  Diabetologia       Date:  1978-08       Impact factor: 10.122

9.  Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.

Authors:  J C Pickup; H Keen; J A Parsons; K G Alberti
Journal:  Br Med J       Date:  1978-01-28

10.  Effects of leg exercise on insulin absorption in diabetic patients.

Authors:  V A Koivisto; P Felig
Journal:  N Engl J Med       Date:  1978-01-12       Impact factor: 91.245
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  31 in total

1.  Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model.

Authors:  S A Charman; D N McLennan; G A Edwards; C J Porter
Journal:  Pharm Res       Date:  2001-11       Impact factor: 4.200

Review 2.  Mechanistic determinants of biotherapeutics absorption following SC administration.

Authors:  Wolfgang F Richter; Suraj G Bhansali; Marilyn E Morris
Journal:  AAPS J       Date:  2012-05-23       Impact factor: 4.009

3.  Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.

Authors:  Nischay K Rege; Nalinda P Wickramasinghe; Alisar N Tustan; Nelson F B Phillips; Vivien C Yee; Faramarz Ismail-Beigi; Michael A Weiss
Journal:  J Biol Chem       Date:  2018-06-07       Impact factor: 5.157

4.  MATHEMATICAL MODELS OF SUBCUTANEOUS INJECTION OF INSULIN ANALOGUES: A MINI-REVIEW.

Authors:  Jiaxu Li; James D Johnson
Journal:  Discrete Continuous Dyn Syst Ser B       Date:  2009-09       Impact factor: 1.327

5.  A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity.

Authors:  Liang Zhang; Tejas Navaratna; Greg M Thurber
Journal:  Bioconjug Chem       Date:  2016-06-29       Impact factor: 4.774

6.  The chemical characterization of the radioactive products derived from [[3H]PheB1]insulin in the circulation of the rat.

Authors:  J G Davies; R E Offord
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

Review 7.  Pharmacokinetics of insulin. Implications for continuous subcutaneous insulin infusion therapy.

Authors:  E W Kraegen; D J Chisholm
Journal:  Clin Pharmacokinet       Date:  1985 Jul-Aug       Impact factor: 6.447

8.  Low subcutaneous degradation and slow absorption of insulin in insulin-dependent diabetic patients during continuous subcutaneous insulin infusion at basal rate.

Authors:  D J Chisholm; E W Kraegen; M J Hewett; S Furler
Journal:  Diabetologia       Date:  1984-08       Impact factor: 10.122

9.  Insulin responses to varying profiles of subcutaneous insulin infusion: kinetic modelling studies.

Authors:  E W Kraegen; D J Chisholm
Journal:  Diabetologia       Date:  1984-03       Impact factor: 10.122

Review 10.  Insulin-dependent (type I) diabetes mellitus.

Authors:  W Rodger
Journal:  CMAJ       Date:  1991-11-15       Impact factor: 8.262
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