Literature DB >> 6378459

Surface IgG subclasses in human B cell lymphomas as revealed by monoclonal antibodies.

E B Smeland, R Jefferis, T Godal.   

Abstract

IgG subclass expression on cells from lymph node biopsies of 17 sIgG positive B cell lymphomas has been studied. Subclass specific monoclonal antibodies were used in an immunoradiometric assay. Ten were also tested by immunofluorescence using a biotin-avidin system. Thirteen of the lymphomas expressed IgG only, while four co-expressed other Ig isotypes. Morphological investigations revealed that 14 lymphomas originated from germinal centre cells. IgG1 was found to be dominant subclass in 10 lymphomas, IgG3 in seven, IgG2 in one, while none expressed IgG4. Multiple IgG subclasses could not be detected in any of the lymphomas tested.

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Year:  1984        PMID： 6378459      PMCID： PMC1536097     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

1.  Surface-bound immunoglobulin on lymphocytes from normal and immunodeficient humans.

Authors:  S S Froland; J B Natvig
Journal:  Scand J Immunol       Date:  1972       Impact factor: 3.487

2.  Antibodies to major histocompatibility antigens produced by hybrid cell lines.

Authors:  G Galfre; S C Howe; C Milstein; G W Butcher; J C Howard
Journal:  Nature       Date:  1977-04-07       Impact factor: 49.962

3.  IgG on lymphocyte surfaces; technical problems and the significance of a third cell population.

Authors:  R J Winchester; S M Fu; T Hoffman; H G Kunkel
Journal:  J Immunol       Date:  1975-04       Impact factor: 5.422

4.  Properties of monoclonal antibodies to human immunoglobulin kappa and lambda chains.

Authors:  J Lowe; D Hardie; R Jefferis; N R Ling; P Drysdale; P Richardson; C Raykundalia; D Catty; P Appleby; R Drew; I C Maclennan
Journal:  Immunology       Date:  1981-04       Impact factor: 7.397

5.  Cell-associated immunoglobulin in human non-Hodgkin lymphomas. A comparative study of surface immunoglobulin on cells in suspension and cytoplasmic immunoglobulin by immunohistochemistry.

Authors:  T O Landaas; T Godal; P F Marton; S Kvaløy; R Langholm; T Lindmo; O G Jørgensen; H Høst
Journal:  Acta Pathol Microbiol Scand A       Date:  1981-03

6.  T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch.

Authors:  P K Mongini; W E Paul; E S Metcalf
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307

7.  Interaction of aggregated -globulin with B lymphocytes.

Authors:  H B Dickler; H G Kunkel
Journal:  J Exp Med       Date:  1972-07-01       Impact factor: 14.307

8.  The nature of the immunoglobulin G on the surface of B lymphocytes in chronic lymphocytic leukemia.

Authors:  F K Stevenson; T J Hamblin; G T Stevenson
Journal:  J Exp Med       Date:  1981-12-01       Impact factor: 14.307

9.  H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN.

Authors:  H M GREY; H G KUNKEL
Journal:  J Exp Med       Date:  1964-08-01       Impact factor: 14.307

10.  Studies of the Vi (gamma-2c) subgroup of gamma-globulin. A relationship between concentration and genetic type among normal individuals.

Authors:  W J Yount; H G Kunkel; S D Litwin
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307
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