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Literature DB >> 6378087

Effect of decreased renal function on the pharmacokinetics of ceftazidime.

B H Ackerman, J Ross, R W Tofte, J C Rotschafer.

Abstract

The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6378087 PMCID： PMC185645 DOI： 10.1128/AAC.25.6.785

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.

Authors: S Riegelman; J C Loo; M Rowland
Journal: J Pharm Sci Date: 1968-01 Impact factor: 3.534

2. Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.

Authors: J C Loo; S Riegelman
Journal: J Pharm Sci Date: 1970-01 Impact factor: 3.534

Review 3. Bactericidal and bacteriolytic activity of serum against gram-negative bacteria.

Authors: P W Taylor
Journal: Microbiol Rev Date: 1983-03

4. Beta-lactamase-producing Bacteroides species in the oral cavity in relation to penicillin therapy.

Authors: A Heimdahl; L von Konow; C E Nord
Journal: J Antimicrob Chemother Date: 1981-09 Impact factor: 5.790

5. Ceftazidime: pharmacokinetics in patients and effects on the renal function.

Authors: S R Norrby; L A Burman; H Linderholm; B Trollfors
Journal: J Antimicrob Chemother Date: 1982-09 Impact factor: 5.790

6. Comparative pharmacokinetics of ceftazidime and moxalactam.

Authors: T B Tjandramaga; A Van Hecken; A Mullie; R Verbesselt; P J De Schepper; L Verbist
Journal: Antimicrob Agents Chemother Date: 1982-08 Impact factor: 5.191

6 in total

7 in total

Effect of decreased renal function on the pharmacokinetics of ceftazidime.

1. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.

2. Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.

Review 3. Bactericidal and bacteriolytic activity of serum against gram-negative bacteria.

4. Beta-lactamase-producing Bacteroides species in the oral cavity in relation to penicillin therapy.

5. Ceftazidime: pharmacokinetics in patients and effects on the renal function.

6. Comparative pharmacokinetics of ceftazidime and moxalactam.

Review 1. Clinical pharmacokinetics of antibiotics in patients with impaired renal function.

2. Population pharmacokinetics of continuous infusion ceftazidime.

Review 3. Clinical pharmacokinetics of newer cephalosporins.

4. Dosage adjustment for ceftazidime in patients with impaired renal function.

5. Correlation of the pharmacokinetic parameters of amikacin and ceftazidime.

6. Comparative pharmacokinetics of ceftazidime in young, healthy and elderly, acutely ill males.

Review 7. Clinical pharmacokinetics of the third generation cephalosporins.