Literature DB >> 6377090

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

J Milner.   

Abstract

The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of p53 protein correlates with this commitment step. I show here that in unstimulated cells, a second form of p53 is synthesized and is restricted to G0.

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Year:  1984        PMID： 6377090     DOI： 10.1038/310143a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  35 in total

1.  Regulation of ES cell differentiation by functional and conformational modulation of p53.

Authors:  K Sabapathy; M Klemm; R Jaenisch; E F Wagner
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

2.  Alternatively spliced p53 RNA in transformed and normal cells of different tissue types.

Authors:  K A Han; M F Kulesz-Martin
Journal:  Nucleic Acids Res       Date:  1992-04-25       Impact factor: 16.971

3.  Monoclonal antibody analysis of p53 expression in normal and transformed cells.

Authors:  J W Yewdell; J V Gannon; D P Lane
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

4.  The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

Authors:  G Selivanova; V Iotsova; E Kiseleva; M Ström; G Bakalkin; R C Grafström; K G Wiman
Journal:  Nucleic Acids Res       Date:  1996-09-15       Impact factor: 16.971

5.  Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule.

Authors:  D Wolf; N Harris; N Goldfinger; V Rotter
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272

6.  Oligomerization of oncoprotein p53.

Authors:  S Kraiss; A Quaiser; M Oren; M Montenarh
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

7.  Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

Authors:  D W Meek; W Eckhart
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

8.  Immunologically distinct p53 molecules generated by alternative splicing.

Authors:  N Arai; D Nomura; K Yokota; D Wolf; E Brill; O Shohat; V Rotter
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

9.  Molecular basis for heterogeneity of the human p53 protein.

Authors:  N Harris; E Brill; O Shohat; M Prokocimer; D Wolf; N Arai; V Rotter
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272

10.  A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.

Authors:  C Gaiddon; M Lokshin; J Ahn; T Zhang; C Prives
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272
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