Literature DB >> 6376358

Species differences in Kupffer cells and endotoxin sensitivity.

R S McCuskey, P A McCuskey, R Urbaschek, B Urbaschek.   

Abstract

The relative species sensitivity to Escherichia coli O111:B4 endotoxin was found to be guinea pig greater than hamster greater than mouse greater than rat. The 50% lethal dose of this endotoxin correlated with both the rate at which single latex particles were phagocytosed by individual Kupffer cells and the number of Kupffer cells in hepatic lobules that phagocytosed latex. The results suggests that the intrahepatic density and the level of activation of Kupffer cells participate in determining endotoxin sensitivity.

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Year:  1984        PMID： 6376358      PMCID： PMC263314          DOI： 10.1128/iai.45.1.278-280.1984

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

1.  In vivo microscopy of the hepatic microvascular system.

Authors:  R S McCuskey; F D Reilly; P A McCuskey; R V Dimlich
Journal:  Bibl Anat       Date:  1979

2.  Aspects of beneficial endotoxin-mediated effects.

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Journal:  Klin Wochenschr       Date:  1982-07-15

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Review 4.  In vivo microscopy of internal organs.

Authors:  R S McCuskey
Journal:  Prog Clin Biol Res       Date:  1981

5.  Uptake by liver cells of endotoxin following its intravenous injection.

Authors:  D J Ruiter; J van der Meulen; A Brouwer; M J Hummel; B J Mauw; J C van der Ploeg; E Wisse
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6.  The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits.

Authors:  J C Mathison; R J Ulevitch
Journal:  J Immunol       Date:  1979-11       Impact factor: 5.422

7.  The response of isolated rabbit hepatic macrophages (H-M macrophage) to lipopolysaccharide (LPS).

Authors:  R V Maier; R J Ulevitch
Journal:  Circ Shock       Date:  1981

8.  Superoxide release by zymosan-stimulated rat Kupffer cells in vitro.

Authors:  R Bhatnagar; R Schirmer; M Ernst; K Decker
Journal:  Eur J Biochem       Date:  1981-09

Review 9.  The inflammatory response to endotoxins.

Authors:  B Urbaschek; R Urbaschek
Journal:  Bibl Anat       Date:  1979

10.  In vivo microscopic studies of the responses of the liver to endotoxin.

Authors:  R S McCuskey; R Urbaschek; P A McCuskey; B Urbaschek
Journal:  Klin Wochenschr       Date:  1982-07-15
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  12 in total

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6.  Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver.

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8.  Endotoxin is angiogenic.

Authors:  I Mattsby-Baltzer; A Jakobsson; J Sörbo; K Norrby
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9.  Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.

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Review 10.  Animal models of sepsis.

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