Literature DB >> 6373460

Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.

A A Rossini, S Slavin, B A Woda, M Geisberg, A A Like, J P Mordes.   

Abstract

Total lymphoid irradiation (TLI) at doses of 2200 rads or greater prevented diabetes in susceptible BB/W rats. Two of 29 (7%) treated rats became diabetic compared with 23 of 39 (59%) controls (P less than 0.001). TLI did not, however, prevent insulitis or thyroiditis in nondiabetic rats, nor did it restore the depressed concanavalin-A responsiveness of BB rat lymphocytes. T-lymphocyte subset proportions were the same in both groups. TLI was associated with significant radiation-related mortality, and nondiabetic TLI-treated rats weighed significantly less than controls. We conclude that TLI is effective in the prevention of BB rat diabetes. However, TLI fails to correct the subclinical immunologic abnormalities of the model and is associated with significant morbidity.

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Year:  1984        PMID： 6373460     DOI： 10.2337/diab.33.6.543

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  10 in total

1.  In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

Authors:  C Boitard; S Michie; P Serrurier; G W Butcher; A P Larkins; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

2.  Bone marrow irradiation chimeras in the BB rat: evidence suggesting two defects leading to diabetes and lymphopoenia.

Authors:  J Scott; V H Engelhard; D C Benjamin
Journal:  Diabetologia       Date:  1987-10       Impact factor: 10.122

3.  Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

Authors:  E S Handler; J P Mordes; J Seals; S Koevary; A A Like; K Nakano; A A Rossini
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

4.  Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells.

Authors:  P MacKay; J Jacobson; A Rabinovitch
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

5.  Prevention of diabetes in BB/Wor rats by intrathymic islet injection.

Authors:  S B Koevary; M Blomberg
Journal:  J Clin Invest       Date:  1992-02       Impact factor: 14.808

6.  Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen.

Authors:  W C Watson; J P Thompson; K Terato; M A Cremer; A H Kang
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307

7.  T cell dysfunction in the diabetes-prone BB rat. A role for thymic migrants that are not T cell precursors.

Authors:  H M Georgiou; A C Lagarde; D Bellgrau
Journal:  J Exp Med       Date:  1988-01-01       Impact factor: 14.307

8.  Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.

Authors:  J Lefkowith; G Schreiner; J Cormier; E S Handler; H K Driscoll; D Greiner; J P Mordes; A A Rossini
Journal:  J Exp Med       Date:  1990-03-01       Impact factor: 14.307

9.  Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.

Authors:  A A Like; C A Biron; E J Weringer; K Byman; E Sroczynski; D L Guberski
Journal:  J Exp Med       Date:  1986-10-01       Impact factor: 14.307

10.  Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

Authors:  D L Greiner; J P Mordes; E S Handler; M Angelillo; N Nakamura; A A Rossini
Journal:  J Exp Med       Date:  1987-08-01       Impact factor: 14.307
  10 in total

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