Literature DB >> 4056046

Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.

E S Handler, J P Mordes, J Seals, S Koevary, A A Like, K Nakano, A A Rossini.   

Abstract

Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.

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Year:  1985        PMID： 4056046      PMCID： PMC424167          DOI： 10.1172/JCI112156

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  9 in total

Review 1.  Altered immunity and diabetes in the BB rat.

Authors:  J F Yale; E B Marliss
Journal:  Clin Exp Immunol       Date:  1984-07       Impact factor: 4.330

Review 2.  Spontaneous autoimmune diabetes mellitus in the BioBreeding/Worcester rat.

Authors:  A A Like; A A Rossini
Journal:  Surv Synth Pathol Res       Date:  1984

3.  Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.

Authors:  A A Rossini; S Slavin; B A Woda; M Geisberg; A A Like; J P Mordes
Journal:  Diabetes       Date:  1984-06       Impact factor: 9.461

4.  Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

Authors:  A A Rossini; D Faustman; B A Woda; A A Like; I Szymanski; J P Mordes
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

5.  T lymphocytes of young and aged rats. I. Distribution, density, and capping of T antigens.

Authors:  S C Gilman; B A Woda; J D Feldman
Journal:  J Immunol       Date:  1981-07       Impact factor: 5.422

6.  Spontaneous autoimmune diabetes mellitus in the BB rat.

Authors:  A A Like; L Butler; R M Williams; M C Appel; E J Weringer; A A Rossini
Journal:  Diabetes       Date:  1982       Impact factor: 9.461

7.  Passive transfer of diabetes in the BB/W rat.

Authors:  S Koevary; A Rossini; W Stoller; W Chick; R M Williams
Journal:  Science       Date:  1983-05-13       Impact factor: 47.728

8.  Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.

Authors:  A A Like; E J Weringer; A Holdash; P McGill; D Atkinson; A A Rossini
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

9.  Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

Authors:  R A Jackson; J B Buse; R Rifai; D Pelletier; E L Milford; C B Carpenter; G S Eisenbarth; R M Williams
Journal:  J Exp Med       Date:  1984-06-01       Impact factor: 14.307
  9 in total
  1 in total

1.  Major histocompatibility complex gene product expression on pancreatic beta cells in acutely diabetic BB rats.

Authors:  B Issa-Chergui; J F Yale; C Vigeant; T A Seemayer
Journal:  Am J Pathol       Date:  1988-01       Impact factor: 4.307
  1 in total

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