Literature DB >> 6369655

A novel series of chemical structures active in vitro against the trypomastigote form of Trypanosoma cruzi.

D J Hammond, B Cover, W E Gutteridge.   

Abstract

A rapid in vitro test system has shown that many drugs which possess a product licensed for use in man are also active at a concentration of less than 1mM against the blood forms of Trypanosoma cruzi. 62 of these are structurally related amphiphilic cationic drugs which completely lyse the trypomastigotes at 4 degrees C within 24 hr, yet most leave the erythrocytes intact. Three polyene and two anthracycline antibiotics were also found to be selectively trypanocidal under the same conditions.

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Year:  1984        PMID： 6369655     DOI： 10.1016/0035-9203(84)90184-6

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  10 in total

Review 1.  Parasite-specific trypanothione reductase as a drug target molecule.

Authors:  R Luise Krauth-Siegel; Oliver Inhoff
Journal:  Parasitol Res       Date:  2003-04-23       Impact factor: 2.289

2.  Disruption of mitochondrial function as the basis of the trypanocidal effect of trifluoperazine on Trypanosoma cruzi.

Authors:  J L Lacuara; S R de Barioglio; P P de Oliva; A S Bernacchi; A F de Culasso; J A Castro; B M Franke de Cazzulo; J J Cazzulo
Journal:  Experientia       Date:  1991-06-15

3.  Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.

Authors:  Juan C Engel; Kenny K H Ang; Steven Chen; Michelle R Arkin; James H McKerrow; Patricia S Doyle
Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191

4.  The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway.

Authors:  Jean Henrique da Silva Rodrigues; Nathielle Miranda; Hélito Volpato; Tânia Ueda-Nakamura; Celso Vataru Nakamura
Journal:  Parasitol Res       Date:  2019-01-29       Impact factor: 2.289

5.  Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata.

Authors:  M N de Tarlovsky; S G Goijman; M P Molina Portela; A O Stoppani
Journal:  Experientia       Date:  1990-05-15

6.  Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

Authors:  F S Buckner; C L Verlinde; A C La Flamme; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

7.  Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.

Authors:  Julien Defaux; Marta Sala; Xavier Formosa; Carles Galdeano; Martin C Taylor; Waleed A A Alobaid; John M Kelly; Colin W Wright; Pelayo Camps; Diego Muñoz-Torrero
Journal:  Bioorg Med Chem       Date:  2011-01-21       Impact factor: 3.641

8.  Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium.

Authors:  P G Pate; J S Wolfson; G L McHugh; S C Pan; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

9.  An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein.

Authors:  Marcele N Rocha; Célia M Corrêa; Maria N Melo; Stephen M Beverley; Olindo Assis Martins-Filho; Ana Paula Madureira; Rodrigo P Soares
Journal:  Diagn Microbiol Infect Dis       Date:  2013-01-10       Impact factor: 2.803

10.  Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi.

Authors:  S G Goijman; J F Turrens; G B Marini-Bettolo; A O Stoppani
Journal:  Experientia       Date:  1985-05-15
  10 in total

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