Literature DB >> 6367635

Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study.

G A Eby, D R Davis, W W Halcomb.   

Abstract

As a possible treatment for common colds, we tested zinc gluconate lozenges in a double-blind, placebo-controlled, clinical trial. One 23-mg zinc lozenge or matched placebo was dissolved in the mouth every 2 wakeful h after an initial double dose. After 7 days, 86% of 37 zinc-treated subjects were asymptomatic, compared with only 46% of 28 placebo-treated subjects (P = 0.0005). Side effects or complaints were usually minor and consisted mainly of objectionable taste and mouth irritation. Zinc lozenges shortened the average duration of common colds by about 7 days.

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Year:  1984        PMID: 6367635      PMCID: PMC185426          DOI: 10.1128/AAC.25.1.20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  16 in total

1.  Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides.

Authors:  B D Korant; B E Butterworth
Journal:  J Virol       Date:  1976-04       Impact factor: 5.103

2.  Effect of zinc ions on synthesis of herpes simplex virus type 2-induced polypeptides.

Authors:  P Gupta; F Rapp
Journal:  Proc Soc Exp Biol Med       Date:  1976-07

3.  Distribution and removal of human serum albumin-technetium 99m instilled intranasally.

Authors:  F Y Aoki; J C Crowley
Journal:  Br J Clin Pharmacol       Date:  1976-10       Impact factor: 4.335

4.  Selective inhibition of herpes simplex virus type 1 DNA polymerase by zinc ions.

Authors:  B Fridlender; N Chejanovsky; Y Becker
Journal:  Virology       Date:  1978-02       Impact factor: 3.616

5.  Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.

Authors:  B E Butterworth; B D Korant
Journal:  J Virol       Date:  1974-08       Impact factor: 5.103

6.  Zinc ions inhibit replication of rhinoviruses.

Authors:  B D Korant; J C Kauer; B E Butterworth
Journal:  Nature       Date:  1974-04-12       Impact factor: 49.962

7.  Acceleration of wound healing in man with zinc sulphate given by mouth.

Authors:  W J Pories; J H Henzel; C G Rob; W H Strain
Journal:  Lancet       Date:  1967-01-21       Impact factor: 79.321

8.  Immunostimulatory effect of zinc in patients with acute lymphoblastic leukemia.

Authors:  M Wazewska-Czyzewska; J Wesierska-Gadek; L Legutko
Journal:  Folia Haematol Int Mag Klin Morphol Blutforsch       Date:  1978

Review 9.  Replication of rhinoviruses.

Authors:  B E Butterworth; R R Grunert; B D Korant; K Lonberg-Holm; F H Yin
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

10.  [Indices of zinc metabolism in leucoses].

Authors:  G G Bogomolova; V M Karlinskiĭ
Journal:  Vrach Delo       Date:  1977-12
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  53 in total

1.  Common cold.

Authors:  Graham Worrall
Journal:  Can Fam Physician       Date:  2011-11       Impact factor: 3.275

2.  PURLs: Zinc for the common cold--not if, but when.

Authors:  Goutham Rao; Kate Rowland
Journal:  J Fam Pract       Date:  2011-11       Impact factor: 0.493

3.  Pharmacokinetic study of orally administered zinc in humans: evidence for an enteral recirculation.

Authors:  J Nève; M Hanocq; A Peretz; F Abi Khalil; F Pelen; J P Famaey; J Fontaine
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Oct-Dec       Impact factor: 2.441

4.  Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors.

Authors:  Fenghua Wang; Cheng Chen; Xuemeng Liu; Kailin Yang; Xiaoling Xu; Haitao Yang
Journal:  J Virol       Date:  2015-12-09       Impact factor: 5.103

5.  Remedies for Common Cold Symptoms: Making sense of myriad drugs.

Authors:  P F Miller
Journal:  Can Fam Physician       Date:  1991-01       Impact factor: 3.275

6.  Protection against membrane-mediated cytotoxicity by calcium and zinc.

Authors:  D Mahadevan; A Ndirika; J Vincent; L Bashford; T Chambers; C Pasternak
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

Review 7.  Viruses as toxins. With special reference to paramyxoviruses. Brief review.

Authors:  C A Pasternak
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

8.  In vitro activity of zinc salts against human rhinoviruses.

Authors:  F C Geist; J A Bateman; F G Hayden
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

9.  Failure of zinc gluconate in treatment of acute upper respiratory tract infections.

Authors:  D S Smith; E C Helzner; C E Nuttall; M Collins; B A Rofman; D Ginsberg; C B Goswick; A Magner
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

10.  The changes of metabolism balance of zinc and copper in gastric juice with widely varying dietary zinc intake.

Authors:  P L Leung; X L Li
Journal:  Biol Trace Elem Res       Date:  1993-10       Impact factor: 3.738

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