Literature DB >> 6365675

Effect of insulin on the transformation of BALB/3T3 cells by X-ray irradiation.

M Umeda, K Tanaka, T Ono.   

Abstract

The effects of triiodothyronine (T3), hydrocortisone, and insulin on X-ray-induced transformation of BALB/3T3 A31-1-1 cloned cells were examined. Under the experimental conditions employed, the addition of 10(-7) M T3 or hydrocortisone to the serum-containing medium had little effect on the transformation. In contrast, the addition of insulin dramatically enhanced the transformation. The effect of insulin was concentration-dependent up to 10 micrograms/ml and was consistently observed with X-rays at various doses.

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Year:  1983        PMID: 6365675

Source DB:  PubMed          Journal:  Gan        ISSN: 0016-450X


  2 in total

1.  Promotion of BALB/3T3 cell transformation by the okadaic acid class of tumor promoters, okadaic acid and dinophysistoxin-1.

Authors:  A Sakai; H Fujiki
Journal:  Jpn J Cancer Res       Date:  1991-05

2.  Isolation and characterization of ras-transfected BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoyl-phorbol-13-acetate.

Authors:  K Sasaki; H Mizusawa; M Ishidate
Journal:  Jpn J Cancer Res       Date:  1988-08
  2 in total

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