Literature DB >> 6365238

Treponema pallidum does not synthesise in vitro a capsule containing glycosaminoglycans or proteoglycans.

R A Strugnell, C J Handley, D A Lowther, S Faine, S R Graves.   

Abstract

Treponema pallidum was investigated for its ability to synthesise glycosaminoglycans or proteoglycans in vitro. Isolated viable T pallidum organisms were incubated with radiolabelled precursors of glycosaminoglycans, sodium 35S-sulphate and 3H-glucosamine (tritiated glucosamine). T pallidum failed to incorporate sodium 35S-sulphate but did incorporate 3H-glucosamine into a macromolecule which may be associated with the surface of the treponeme. This macromolecule was resistant to degradation by specific glycosaminoglycanases. We conclude that T pallidum does not synthesise a capsule containing glycosaminoglycans in vitro.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6365238      PMCID： PMC1046262          DOI： 10.1136/sti.60.1.8

Source DB:  PubMed          Journal:  Br J Vener Dis        ISSN： 0007-134X


  18 in total

1.  A modified uronic acid carbazole reaction.

Authors:  T BITTER; H M MUIR
Journal:  Anal Biochem       Date:  1962-10       Impact factor: 3.365

2.  Environmental control of macromolecular synthesis in cartilage and bone: morphogenetic response to hyaluronidase.

Authors:  S F Jackson
Journal:  Proc R Soc Lond B Biol Sci       Date:  1970-09-29

3.  A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate.

Authors:  A Wasteson
Journal:  J Chromatogr       Date:  1971-07-08

4.  Purification and properties of bacterial chondroitinases and chondrosulfatases.

Authors:  T Yamagata; H Saito; O Habuchi; S Suzuki
Journal:  J Biol Chem       Date:  1968-04-10       Impact factor: 5.157

5.  Electrophysiological dysfunction and cellular disruption of sensory neurones during incubation with Treponema pallidum.

Authors:  S G Oakes; L A Repesh; R S Pozos; T J Fitzgerald
Journal:  Br J Vener Dis       Date:  1982-08

6.  Effects of anaerobic and microaerophilic conditions of extraction and incubation on the survival of Treponema pallidum in vitro.

Authors:  G H Wong; B M Steiner; S R Graves
Journal:  Br J Vener Dis       Date:  1982-06

Review 7.  Pathogenesis and immunology of Treponema pallidum.

Authors:  T J Fitzgerald
Journal:  Annu Rev Microbiol       Date:  1981       Impact factor: 15.500

8.  Surface-associated host proteins on virulent Treponema pallidum.

Authors:  J F Alderete; J B Baseman
Journal:  Infect Immun       Date:  1979-12       Impact factor: 3.441

9.  Surface mucopolysaccharides of Treponema pallidum.

Authors:  T J Fitzgerald; R C Johnson
Journal:  Infect Immun       Date:  1979-04       Impact factor: 3.441

10.  Reappraisal of lymphocyte responsiveness to concanavalin A during experimental syphilis: evidence that glycosaminoglycans in the sera and tissues interfere ith active binding sites on the lectin and not with the lymphocytes.

Authors:  R E Baughn; D M Musher
Journal:  Infect Immun       Date:  1982-02       Impact factor: 3.441
View more
  6 in total

1.  Light and electron microscopy of rabbit testes infected with Treponema pallidum (Nichols strain): nature of deposited mucopolysaccharides and localisation of treponemes.

Authors:  J J van der Sluis; F J ten Kate; V D Vuzevski; E Stolz
Journal:  Genitourin Med       Date:  1987-10

2.  Characterization of the proteoglycans synthesized by rabbit testis in response to infection by Treponema pallidum.

Authors:  R A Strugnell; C J Handley; L P Drummond; S Faine
Journal:  Am J Pathol       Date:  1986-08       Impact factor: 4.307

3.  Opsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemes.

Authors:  J M Shaffer; S A Baker-Zander; S A Lukehart
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

Review 4.  Investigation of the immune escape mechanism of Treponema pallidum.

Authors:  Yun Tang; Yingjie Zhou; Bisha He; Ting Cao; Xiangping Zhou; Lichang Ning; En Chen; Yumeng Li; Xiaoping Xie; Binfeng Peng; Yibao Hu; Shuangquan Liu
Journal:  Infection       Date:  2022-10-19       Impact factor: 7.455

5.  Polyanions in syphilis: evidence that glycoproteins and macromolecules resembling glycosaminoglycans are synthesised by host tissues in response to infection with Treponema pallidum.

Authors:  R A Strugnell; C J Handley; L Drummond; S Faine; D A Lowther; S R Graves
Journal:  Br J Vener Dis       Date:  1984-04

6.  Experimental syphilitic orchitis. Relationship between Treponema pallidum infection and testis synthesis of proteoglycans.

Authors:  R A Strugnell; T Kent; C J Handley; S Faine
Journal:  Am J Pathol       Date:  1988-10       Impact factor: 4.307
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.