Literature DB >> 6364130

Monoclonal antibodies to human urokinase identify the single-chain pro-urokinase precursor.

G Salerno, P Verde, M L Nolli, A Corti, H Szöts, T Meo, J Johnson, S Bullock, G Cassani, F Blasi.   

Abstract

Monoclonal antibodies have been obtained that recognize either the A or B chain of human urinary urokinase. These antibodies identify human urokinase-producing cells and the product of urokinase mRNA. Anti-urokinase monoclonal antibodies precipitate an approximately equal to 54,000-dalton protein synthesized in vitro in a rabbit reticulocyte cell-free system. This pro-urokinase appears to be the precursor of both A and B chains of human urinary urokinase. Urokinase mRNA in human kidney constitutes only 0.1% or less of total poly(A)+ RNA.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6364130      PMCID： PMC344620          DOI： 10.1073/pnas.81.1.110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors:  J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

2.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

3.  Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.

Authors:  R A Laskey; A D Mills
Journal:  Eur J Biochem       Date:  1975-08-15

4.  SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.

Authors:  J W LITTLEFIELD
Journal:  Science       Date:  1964-08-14       Impact factor: 47.728

5.  Tumour promotor induces plasminogen activator.

Authors:  M Wigler; I B Weinstein
Journal:  Nature       Date:  1976-01-22       Impact factor: 49.962

6.  Primary activation of the vitellogenin gene in the rooster.

Authors:  R G Deeley; J I Gordon; A T Burns; K P Mullinix; M Binastein; R F Goldberg
Journal:  J Biol Chem       Date:  1977-11-25       Impact factor: 5.157

7.  The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

Authors:  S Strickland; V Mahdavi
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

8.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

9.  An efficient mRNA-dependent translation system from reticulocyte lysates.

Authors:  H R Pelham; R J Jackson
Journal:  Eur J Biochem       Date:  1976-08-01

10.  Plasminogen activator: induction of synthesis by DNA damage.

Authors:  R Miskin; E Reich
Journal:  Cell       Date:  1980-01       Impact factor: 41.582
View more
  12 in total

1.  Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.

Authors:  M Debatisse; I Saito; G Buttin; G R Stark
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

2.  Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

Authors:  M P Stoppelli; A Corti; A Soffientini; G Cassani; F Blasi; R K Assoian
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

3.  Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.

Authors:  Victoria Stepanova; Padma-Sheela Jayaraman; Sergei V Zaitsev; Tatiana Lebedeva; Khalil Bdeir; Rachael Kershaw; Kelci R Holman; Yelena V Parfyonova; Ekaterina V Semina; Irina B Beloglazova; Vsevolod A Tkachuk; Douglas B Cines
Journal:  J Biol Chem       Date:  2016-05-04       Impact factor: 5.157

4.  The human urokinase-plasminogen activator gene and its promoter.

Authors:  A Riccio; G Grimaldi; P Verde; G Sebastio; S Boast; F Blasi
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

5.  Human urokinase gene is located on the long arm of chromosome 10.

Authors:  P Tripputi; F Blasi; P Verde; L A Cannizzaro; B S Emanuel; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

6.  Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

Authors:  P Verde; M P Stoppelli; P Galeffi; P Di Nocera; F Blasi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

7.  Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function.

Authors:  E Verpy; E Couture-Tosi; E Eldering; M Lopez-Trascasa; P Späth; T Meo; M Tosi
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

8.  cDNA cloning of the immunoglobulin heavy chain binding protein.

Authors:  I G Haas; T Meo
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

9.  Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.

Authors:  A C Webb; K L Collins; S E Snyder; S J Alexander; L J Rosenwasser; R L Eddy; T B Shows; P E Auron
Journal:  J Exp Med       Date:  1987-07-01       Impact factor: 14.307

10.  Increase in urokinase plasminogen activator mRNA synthesis in human carcinoma cells is a primary effect of the potent tumor promoter, phorbol myristate acetate.

Authors:  M P Stoppelli; P Verde; G Grimaldi; E K Locatelli; F Blasi
Journal:  J Cell Biol       Date:  1986-04       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.