Literature DB >> 6363677

Effects of vasoactive intestinal polypeptide on renal function in man.

J Calam, R Dimaline, W S Peart, J Singh, R J Unwin.   

Abstract

Six healthy males received vasoactive intestinal polypeptide (VIP; 6 pmol kg-1 min-1) by intravenous infusion for 90 min, with 60 min control periods before and after. Plasma VIP levels rose by about 100 pmol l-1 during the infusion. VIP produced changes in heart rate and blood pressure consistent with generalized vasodilatation, but there were no significant changes in effective renal plasma flow or glomerular filtration rate. Both plasma solids and haematocrit rose by about 5%, suggesting that haemoconcentration had occurred during VIP infusion. Urine flow fell to about a third, and the fractional excretion of sodium, potassium, chloride and calcium fell to between half and two-thirds of control values. Fractional excretion of phosphate did not fall significantly. Plasma renin activity rose about 3-fold during VIP infusion.

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Year:  1983        PMID： 6363677      PMCID： PMC1193808          DOI： 10.1113/jphysiol.1983.sp014989

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  12 in total

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Journal:  Ann N Y Acad Sci       Date:  1962-10-31       Impact factor: 5.691

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Authors:  J P Ripoll
Journal:  Clin Chim Acta       Date:  1976-10-01       Impact factor: 3.786

Review 4.  Renin release.

Authors:  W S Peart
Journal:  Gen Pharmacol       Date:  1978

5.  Adrenergic component of renin release induced by vasodilating antihypertensive drugs in the rat.

Authors:  W A Pettinger; W B Campbell; K Keeton
Journal:  Circ Res       Date:  1973-07       Impact factor: 17.367

Review 6.  Capillary fluid filtration. Starling forces and lymph flow.

Authors:  A E Taylor
Journal:  Circ Res       Date:  1981-09       Impact factor: 17.367

7.  The gut hormone profile of fulminant hepatic failure.

Authors:  S N Sullivan; R A Chase; N D Christofides; S R Bloom; R Williams
Journal:  Am J Gastroenterol       Date:  1981-10       Impact factor: 10.864

8.  Effects of vasoactive intestinal polypeptide (VIP) on renal function and plasma renin activity in the conscious rabbit.

Authors:  R Dimaline; W S Peart; R J Unwin
Journal:  J Physiol       Date:  1983-11       Impact factor: 5.182

9.  Ethnic differences in blood pressure with observations on noradrenaline and renin. A hospital hypertensive population.

Authors:  P S Sever; W S Peart; I B Davies; R D Tunbridge; D Gordon
Journal:  Clin Exp Hypertens       Date:  1979       Impact factor: 1.749

10.  Multiple immunoreactive forms of vasoactive intestinal peptide in human colonic mucosa.

Authors:  R Dimaline; G J Dockray
Journal:  Gastroenterology       Date:  1978-09       Impact factor: 22.682
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  8 in total

1.  Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.

Authors:  B G Charlton; D E Neal; N L Simmons
Journal:  J Physiol       Date:  1990-04       Impact factor: 5.182

2.  Distribution of vasoactive intestinal peptide-sensitive adenylate cyclase activity along the rabbit nephron.

Authors:  N M Griffiths; D Chabardès; M Imbert-Teboul; S Siaume-Perez; F Morel; N L Simmons
Journal:  Pflugers Arch       Date:  1988-09       Impact factor: 3.657

3.  'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Authors:  M Sutters; D J Carmichael; R J Unwin; C Sozi; M Hunter; J Calam; S L Lightman; W S Peart
Journal:  Gut       Date:  1991-06       Impact factor: 23.059

4.  Vasoactive intestinal polypeptide regulation of rabbit renal adenylate cyclase activity in vitro.

Authors:  N M Griffiths; N L Simmons
Journal:  J Physiol       Date:  1987-06       Impact factor: 5.182

5.  Vasoactive intestinal peptide stimulation of renal adenylate cyclase and antagonism by (4Cl-D-Phe6Leu17)VIP.

Authors:  N M Griffiths; N L Simmons; J Rivier
Journal:  Pflugers Arch       Date:  1989-06       Impact factor: 3.657

6.  Effects of indomethacin and (+/-)-propranolol on the cardiovascular and renin responses to vasoactive intestinal polypeptide (VIP) infusion in man.

Authors:  R J Unwin; T Reed; S Thom; J Calam; W S Peart
Journal:  Br J Clin Pharmacol       Date:  1987-05       Impact factor: 4.335

7.  Renal effects of gastrin C-terminal tetrapeptide (as pentagastrin) and cholecystokinin octapeptide in conscious rabbit and man.

Authors:  J Calam; D Gordon; W S Peart; S A Taylor; R J Unwin
Journal:  Br J Pharmacol       Date:  1987-06       Impact factor: 8.739

8.  A comparison of the ventilatory, cardiovascular and metabolic effects of salbutamol, aminophylline and vasoactive intestinal peptide in normal subjects.

Authors:  A H Morice; P Schofield; E E Keal; P S Sever
Journal:  Br J Clin Pharmacol       Date:  1986-08       Impact factor: 4.335
  8 in total

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