Literature DB >> 2167366

Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.

B G Charlton1, D E Neal, N L Simmons.   

Abstract

1. A direct action of vasoactive intestinal peptide (VIP) upon human kidney was sought by measurement of renal adenylate cyclase in tissue homogenates and plasma membranes isolated from tissue samples excised for therapeutic reasons. 2. VIP (1 microM) produced a mean stimulation of adenylate cyclase activity of 3.5-fold compared to basal values in cortical plasma membranes; comparative stimulations of 2.8-fold and 27.3-fold were obtained with 1 microM-glucagon and 1 microM-h(1-34) parathyroid hormone respectively. 3. Half-maximal stimulation of human renal cortical plasma membrane adenylate cyclase was observed with a mean value of 35 nM-VIP. 4. The stimulation of renal adenylate cyclase by VIP appeared to be specific because stimulation by glucagon was additive to that obtained with VIP, and the VIP receptor antagonist (4 Cl-D-Phe6, Leu17)-VIP inhibited the VIP-dependent stimulation of adenylate cyclase activity.

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Year:  1990        PMID： 2167366      PMCID： PMC1189769          DOI： 10.1113/jphysiol.1990.sp018034

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  21 in total

1.  Glucagon-sensitive adenylate cyclase in human renal medulla.

Authors:  J B Mulvehill; Y S Hui; L D Barnes; P J Palumbo; T P Dousa
Journal:  J Clin Endocrinol Metab       Date:  1976-02       Impact factor: 5.958

2.  Distribution of vasoactive intestinal peptide-sensitive adenylate cyclase activity along the rabbit nephron.

Authors:  N M Griffiths; D Chabardès; M Imbert-Teboul; S Siaume-Perez; F Morel; N L Simmons
Journal:  Pflugers Arch       Date:  1988-09       Impact factor: 3.657

3.  Vasoactive intestinal peptide: a direct renal natriuretic substance.

Authors:  K A Duggan; G J Macdonald
Journal:  Clin Sci (Lond)       Date:  1987-02       Impact factor: 6.124

4.  Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide.

Authors:  M Bodanszky; Y S Klausner; S I Said
Journal:  Proc Natl Acad Sci U S A       Date:  1973-02       Impact factor: 11.205

5.  Polypeptide with broad biological activity: isolation from small intestine.

Authors:  S I Said; V Mutt
Journal:  Science       Date:  1970-09-18       Impact factor: 47.728

6.  Vasoactive intestinal peptide control of renal adenylate cyclase: in vitro studies of canine renal membranes and cultured canine renal epithelial (MDCK) cells.

Authors:  N M Griffiths; E L Rugg; N L Simmons
Journal:  Q J Exp Physiol       Date:  1989-05

7.  Vasoactive intestinal polypeptide regulation of rabbit renal adenylate cyclase activity in vitro.

Authors:  N M Griffiths; N L Simmons
Journal:  J Physiol       Date:  1987-06       Impact factor: 5.182

8.  Vasoactive intestinal peptide stimulation of renal adenylate cyclase and antagonism by (4Cl-D-Phe6Leu17)VIP.

Authors:  N M Griffiths; N L Simmons; J Rivier
Journal:  Pflugers Arch       Date:  1989-06       Impact factor: 3.657

9.  High- and low-affinity binding sites for vasoactive intestinal peptide (VIP) in the rat kidney revealed by light microscopic autoradiography.

Authors:  P J Magistretti; P R Hof; J L Martin; M Dietl; J M Palacios
Journal:  Regul Pept       Date:  1988-11

10.  Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves.

Authors:  M Reinecke; W G Forssmann
Journal:  Histochemistry       Date:  1988
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