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Literature DB >> 6359059

Selective inactivation of the 3' to 5' exonuclease activity of Escherichia coli DNA polymerase I by heat.

Abstract

Heat selectively inactivates the 3' to 5' exonuclease activity of E. coli DNA polymerase I, resulting in reduced dNTP turnover and lower fidelity of replication of homopolymer and natural DNA templates.

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Year: 1983 PMID： 6359059 PMCID： PMC326498 DOI： 10.1093/nar/11.21.7505

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

24 in total

1. Manganese as a mutagenic agent during in vitro DNA synthesis.

Authors: D K Dube; L A Loeb
Journal: Biochem Biophys Res Commun Date: 1975-12-01 Impact factor: 3.575

2. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

Authors: N Muzyczka; R L Poland; M J Bessman
Journal: J Biol Chem Date: 1972-11-25 Impact factor: 5.157

3. On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation.

Authors: M S Hershfield
Journal: J Biol Chem Date: 1973-02-25 Impact factor: 5.157

4. Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase.

Authors: M S Hershfield; N G Nossal
Journal: J Biol Chem Date: 1972-06-10 Impact factor: 5.157

5. Studies on the biochemical basis of spontaneous mutation. II. The incorporation of a base and its analogue into DNA by wild-type, mutator and antimutator DNA polymerases.

Authors: M J Bessman; N Muzyczka; M F Goodman; R L Schnaar
Journal: J Mol Biol Date: 1974-09-15 Impact factor: 5.469

6. Enzymatic synthesis of deoxyribonucleic acid. 36. A proofreading function for the 3' leads to 5' exonuclease activity in deoxyribonucleic acid polymerases.

Authors: D Brutlag; A Kornberg
Journal: J Biol Chem Date: 1972-01-10 Impact factor: 5.157

7. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.

Authors: J J Hopfield
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

8. Enzymatic synthesis of deoxyribonucleic acid. XXXV. A 3'-hydroxylribonucleotide binding site of Escherichia coli deoxyribonucleic acid polymerase.

Authors: J A Huberman; A Kornberg
Journal: J Biol Chem Date: 1970-10-25 Impact factor: 5.157