Literature DB >> 6358900

Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.

M D Walker, T Edlund, A M Boulet, W J Rutter.   

Abstract

DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymotrypsin gene recombinant elicits preferential expression in chymotrypsin-producing cells. Sequences located upstream of previously defined transcriptional control elements are essential for efficient expression in both cases.

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Year:  1983        PMID： 6358900     DOI： 10.1038/306557a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  232 in total

1.  The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

Authors:  K Ohneda; R G Mirmira; J Wang; J D Johnson; M S German
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

2.  Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1.

Authors:  Arthur Liberzon; Gabriela Ridner; Michael D Walker
Journal:  Nucleic Acids Res       Date:  2004-01-02       Impact factor: 16.971

3.  GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.

Authors:  Keren Bahar Halpern; Anna Veprik; Nir Rubins; Orly Naaman; Michael D Walker
Journal:  J Biol Chem       Date:  2012-04-09       Impact factor: 5.157

4.  Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.

Authors:  S R Cordle; J Whelan; E Henderson; H Masuoka; P A Weil; R Stein
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

5.  Characterization of a pollen-specific gene family from Brassica napus which is activated during early microspore development.

Authors:  D Albani; L S Robert; P A Donaldson; I Altosaar; P G Arnison; S F Fabijanski
Journal:  Plant Mol Biol       Date:  1990-10       Impact factor: 4.076

6.  A region of basic amino-acid cluster in HIV-1 Tat protein is essential for trans-acting activity and nucleolar localization.

Authors:  S Endo; S Kubota; H Siomi; A Adachi; S Oroszlan; M Maki; M Hatanaka
Journal:  Virus Genes       Date:  1989-11       Impact factor: 2.332

7.  Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

Authors:  Elke Oetjen; Daniela Grapentin; Roland Blume; Michael Seeger; Doris Krause; Anke Eggers; Willhart Knepel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-02-20       Impact factor: 3.000

8.  Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

Authors:  J Whelan; D Poon; P A Weil; R Stein
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

9.  A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.

Authors:  R Herrera; H S Ro; G S Robinson; K G Xanthopoulos; B M Spiegelman
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

10.  The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

Authors:  I Kola; S Brookes; A R Green; R Garber; M Tymms; T S Papas; A Seth
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205
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