| Literature DB >> 6358231 |
P A Farrands, A Perkins, L Sully, J S Hopkins, M V Pimm, R W Baldwin, J D Hardcastle.
Abstract
Immunoscintigraphy using radioisotope-labelled monoclonal antibody prepared against osteosarcoma 791T cells was used to detect a primary osteosarcoma. The eight-centimetre tumour was detected using rectilinear scintigraphy of 131I-labelled antibodies. Image enhancement was achieved by subtraction of blood-pool radioactivity labelled with technetium-99m. The ratio of tumour to non-tumour uptake of radioactivity (5:1) suggested that antibody targeting of therapeutic agents is feasible.Entities:
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Year: 1983 PMID： 6358231
Source DB: PubMed Journal: J Bone Joint Surg Br ISSN： 0301-620X