Literature DB >> 6357575

Cationic antigens in poststreptococcal glomerulonephritis.

A Vogt, S Batsford, B Rodríguez-Iturbe, R García.   

Abstract

Antigen charge is an important factor in the pathogenesis of experimental immune complex glomerulonephritis. Its potential role in man was investigated in post-streptococcal glomerulonephritis, a disease where the causative agent is known. Cationic, extracellular streptococcal antigens were detected in 8 of 18 renal biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). The antigen was found mainly in earlier biopsies in which both IgG and IgM were present. Patients' sera taken at the time of biopsy contained antibody to cationic, streptococcal antigens. Cationic moieties are known to have affinity for the glomerular basement membrane and it is possible that the type of antigen described here initiates APSGN via in situ immune complex formation.

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Year:  1983        PMID： 6357575

Source DB:  PubMed          Journal:  Clin Nephrol        ISSN： 0301-0430            Impact factor:   0.975


  25 in total

1.  Influence of the electric charge of the antigen and the immune complex (IC) lattice on the IC activation of human complement.

Authors:  M A Michelin; L S P Crott; A I Assis-Pandochi; T M Coimbra; J E Teixeira; J E Barbosa
Journal:  Int J Exp Pathol       Date:  2002-04       Impact factor: 1.925

Review 2.  Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis.

Authors:  T Matthew Eison; Bettina H Ault; Deborah P Jones; Russell W Chesney; Robert J Wyatt
Journal:  Pediatr Nephrol       Date:  2010-07-23       Impact factor: 3.714

3.  Purification and partial characterization of the nephritis strain-associated protein from Streptococcus pyogenes, group A.

Authors:  K H Johnston; J B Zabriskie
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307

4.  Mitogenic activity of extracellular cationic products produced by group A streptococci; analysis of the lymphocyte response.

Authors:  M Suzuki; A Vogt
Journal:  Clin Exp Immunol       Date:  1986-10       Impact factor: 4.330

5.  Isolation and characterization of a Streptococcus pyogenes protein that binds to basal laminae of human cardiac muscle.

Authors:  B D Winters; N Ramasubbu; M W Stinson
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

Review 6.  An evaluation of experimental models of glomerulonephritis.

Authors:  P N Furness; K Harris
Journal:  Int J Exp Pathol       Date:  1994-02       Impact factor: 1.925

7.  Streptococcal zymogen type B induces angiotensin II in mesangial cells and leukocytes.

Authors:  Ninoska Viera; Adriana Pedreanez; Jaimar Rincon; Jesus Mosquera
Journal:  Pediatr Nephrol       Date:  2009-01-29       Impact factor: 3.714

8.  Preservation of fixed anionic sites in the GBM in the acute proteinuric phase of cationic antigen mediated in-situ immune complex glomerulonephritis in the rat.

Authors:  Y Suzuki; Y Maruyama; M Arakawa; T Oite
Journal:  Histochemistry       Date:  1984

9.  Electrical charge of a protein determines penetration and localization in hyaline articular cartilage. Quantitative and autoradiographic studies on cartilage of different species, including man.

Authors:  P L van Lent; W B van den Berg; L B van de Putte; L van den Bersselaar
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

10.  Poststreptococcal glomerulonephritis flare-up in a patient with varicella infection.

Authors:  J A Fuhrer; M J Mihatsch; R A Streuli
Journal:  Klin Wochenschr       Date:  1990-12-04
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