Literature DB >> 3542316

Mitogenic activity of extracellular cationic products produced by group A streptococci; analysis of the lymphocyte response.

M Suzuki, A Vogt.   

Abstract

The cationic fraction (isoelectric point greater than 8.5) of supernatant products of group A streptococcal cultures exerted a strong mitogenic effect on human peripheral lymphocytes at concentrations as low as 1 ng/well. Incorporation rates were highest at concentrations of 1-10 micrograms; rabbit peripheral lymphocytes also responded strongly, only a weak response was seen with mouse peripheral lymphocytes and rabbit thymocytes. Purified OKT4 positive (T helper) and OKT8 positive (T suppressor) lymphocyte subpopulations both responded, the former more strongly. Although accessory cells (monocytes) were not absolutely necessary, in their presence higher incorporation of 3H-thymidine was observed. Isolated B cells did not respond.

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Year:  1986        PMID： 3542316      PMCID： PMC1542664     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  10 in total

1.  Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method.

Authors:  K J Bross; G A Pangalis; C G Staatz; K G Blume
Journal:  Transplantation       Date:  1978-06       Impact factor: 4.939

2.  Lymphocyte transformation and macrophage migration inhibition by electrofocused and gel-filtered fractions of group A streptococcal filtrate.

Authors:  E Seravalli; A Taranta
Journal:  Cell Immunol       Date:  1974-12       Impact factor: 4.868

3.  Lymphocytic responses to streptococcal antigens in glomerulonephritic patients.

Authors:  J B Zabriskie; R Lewshenia; G Möller; B Wehle; R E Falk
Journal:  Science       Date:  1970-05-29       Impact factor: 47.728

4.  A plaque assay for all cells secreting Ig of a given type or class.

Authors:  E Gronowicz; A Coutinho; F Melchers
Journal:  Eur J Immunol       Date:  1976-08       Impact factor: 5.532

5.  Isolation and characterization of erythrogenic toxins. V. Communication: identity of erythrogenic toxin type B and streptococcal proteinase precursor.

Authors:  D Gerlach; H Knöll; W Köhler; J H Ozegowski; V Hríbalova
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1983-09

6.  A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

Authors:  T Uchiyama; D L Nelson; T A Fleisher; T A Waldmann
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

7.  Growth characteristics of group A streptococci in a new chemically defined medium.

Authors:  I van de Rijn; R E Kessler
Journal:  Infect Immun       Date:  1980-02       Impact factor: 3.441

8.  Nonspecific and specific immunological mitogenicity by group A streptococcal pyrogenic exotoxins.

Authors:  E L Barsumian; P M Schlievert; D W Watson
Journal:  Infect Immun       Date:  1978-12       Impact factor: 3.441

9.  Cationic antigens in poststreptococcal glomerulonephritis.

Authors:  A Vogt; S Batsford; B Rodríguez-Iturbe; R García
Journal:  Clin Nephrol       Date:  1983-12       Impact factor: 0.975

10.  Purification and properties of an extracellular blastogen produced by group A streptococci.

Authors:  E D Gray
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307
  10 in total
  3 in total

1.  Cationic immune complex arthritis in mice--a new model. Synergistic effect of complement and interleukin-1.

Authors:  P L van Lent; L A van den Bersselaar; A E van den Hoek; A A van de Loo; W B van den Berg
Journal:  Am J Pathol       Date:  1992-06       Impact factor: 4.307

2.  Antibody levels and in vitro lymphoproliferative responses to Streptococcus pyogenes erythrogenic toxin A and mitogen of patients with rheumatic fever.

Authors:  G M Bahr; A M Yousof; K Behbehani; H A Majeed; S Sakkalah; K Souan; I Jarrad; C Geoffroy; J E Alouf
Journal:  J Clin Microbiol       Date:  1991-09       Impact factor: 5.948

3.  Allergic arthritis induced by cationic antigens: relationship of chronicity with antigen retention and T-cell reactivity.

Authors:  P L van Lent; W B van den Berg; J Schalkwijk; L B van de Putte; L van den Bersselaar
Journal:  Immunology       Date:  1987-10       Impact factor: 7.397
  3 in total

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