Literature DB >> 6357073

Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.

J León, J M García-Lobo, J M Ortiz.   

Abstract

The target enzyme for fosfomycin antibiotic action, enolpyruvyl transferase, was synthesized in similar amounts and with similar kinetic and inhibition constants for phosphoenolpyruvate and fosfomycin, respectively, by an Escherichia coli strain containing the fosfomycin resistance plasmid pOU900 and by plasmid-free strains. Neither phosphoenolpyruvate level nor murein synthesis was altered by pOU900.

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Year:  1983        PMID： 6357073      PMCID： PMC185151          DOI： 10.1128/AAC.24.2.276

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  The hexose phosphate transport system of Escherichia coli.

Authors:  G W Dietz
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1976

2.  A stable enzyme-phosphoenolpyruvate intermediate in the synthesis of uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-O-enolpyruvyl ether.

Authors:  P J Cassidy; F M Kahan
Journal:  Biochemistry       Date:  1973-03-27       Impact factor: 3.162

3.  Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.

Authors:  J León; J M García-Lobo; J M Ortiz
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

4.  Tn292l, a transposon encoding fosfomycin resistance.

Authors:  J M García-Lobo; J M Ortiz
Journal:  J Bacteriol       Date:  1982-07       Impact factor: 3.490

5.  Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam.

Authors:  J Berenguer; M A de Pedro; D Vázquez
Journal:  Antimicrob Agents Chemother       Date:  1982-02       Impact factor: 5.191
  5 in total
  2 in total

Review 1.  Plasmid-encoded fosfomycin resistance.

Authors:  J E Suárez; M C Mendoza
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

2.  Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

Authors:  J Llaneza; C J Villar; J A Salas; J E Suarez; M C Mendoza; C Hardisson
Journal:  Antimicrob Agents Chemother       Date:  1985-07       Impact factor: 5.191
  2 in total

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