Literature DB >> 3899003

Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.

J Llaneza, C J Villar, J A Salas, J E Suarez, M C Mendoza, C Hardisson.   

Abstract

The molecular mechanism of plasmid-mediated resistance to fosfomycin is described. The antibiotic was inactivated intracellularly and remained inside the cells. Modification was also obtained from cell extracts and was not energy dependent. The modifying enzyme seems to have sulfhydryl groups in its active center.

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Year:  1985        PMID： 3899003      PMCID： PMC176334          DOI： 10.1128/AAC.28.1.163

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Cloning and expression in minicells of the determinant of resistance to fosfomycin from the transposon Tn2921.

Authors:  J M García-Lobo; J León; J Navas; J M Ortiz
Journal:  Plasmid       Date:  1984-05       Impact factor: 3.466

2.  Charactertization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro.

Authors:  T Tsuruoka; Y Yamada
Journal:  J Antibiot (Tokyo)       Date:  1975-11       Impact factor: 2.649

3.  [Prevalence and dispersion of plasmids conferring fosfomycin resistance in enterobacteria].

Authors:  C Hardisson; C J Villar; J Llaneza; M C Mendoza
Journal:  Pathol Biol (Paris)       Date:  1984-09

4.  Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.

Authors:  J León; J M García-Lobo; J M Ortiz
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

5.  Plasmid-determined resistance to fosfomycin in Serratia marcescens.

Authors:  C Mendoza; J M Garcia; J Llaneza; F J Mendez; C Hardisson; J M Ortiz
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

6.  Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.

Authors:  J León; J M García-Lobo; J M Ortiz
Journal:  Antimicrob Agents Chemother       Date:  1983-08       Impact factor: 5.191

7.  The mechanism of action of fosfomycin (phosphonomycin).

Authors:  F M Kahan; J S Kahan; P J Cassidy; H Kropp
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691
  7 in total
  13 in total

Review 1.  Plasmid-encoded fosfomycin resistance.

Authors:  J E Suárez; M C Mendoza
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

Review 2.  Fosfomycin: an old, new friend?

Authors:  M Popovic; D Steinort; S Pillai; C Joukhadar
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-11-14       Impact factor: 3.267

3.  Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria.

Authors:  P Arca; M Rico; A F Braña; C J Villar; C Hardisson; J E Suárez
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

4.  Glutathione-dependent conversion of N-ethylmaleimide to the maleamic acid by Escherichia coli: an intracellular detoxification process.

Authors:  D McLaggan; H Rufino; M Jaspars; I R Booth
Journal:  Appl Environ Microbiol       Date:  2000-04       Impact factor: 4.792

5.  Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

Authors:  C Thauvin; J F Lemeland; G Humbert; J P Fillastre
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

6.  Cloning and molecular epidemiology of plasmid-determined fosfomycin resistance.

Authors:  C J Villar; C Hardisson; J E Suárez
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

Review 7.  Coagulase-negative staphylococci.

Authors:  Karsten Becker; Christine Heilmann; Georg Peters
Journal:  Clin Microbiol Rev       Date:  2014-10       Impact factor: 26.132

Review 8.  Differences in Fosfomycin Resistance Mechanisms between Pseudomonas aeruginosa and Enterobacterales.

Authors:  Dina Zheng; Phillip J Bergen; Cornelia B Landersdorfer; Elizabeth B Hirsch
Journal:  Antimicrob Agents Chemother       Date:  2021-11-22       Impact factor: 5.938

9.  Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrate.

Authors:  P García; P Arca; J Evaristo Suárez
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

10.  Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.

Authors:  Matthew K Thompson; Mary E Keithly; Michael C Goodman; Neal D Hammer; Paul D Cook; Kevin L Jagessar; Joel Harp; Eric P Skaar; Richard N Armstrong
Journal:  Biochemistry       Date:  2014-01-21       Impact factor: 3.162
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