Literature DB >> 6348756

IgA1 and IgA2 in circulating immune complexes and in renal deposits of Berger's and Schönlein-Henoch glomerulonephritis.

R Coppo, B Basolo, G Mazzucco, M R Bulzomì, D Roccatello, M Messina, G Barbiano, G Martina, C Rollino, G Piccoli.   

Abstract

IgA subclasses in circulating immune complexes (IgA1IC), serum immunoglobulins and mesangial deposits in Berger's and Schönlein-Henoch glomerulonephritis (GN) were studied. Both IgA1IC and IgA2IC were significantly higher in Berger's and Schönlein-Henoch GN than in healthy people. In phases of clinical activity both IgAIC subclasses further increased. The IgA1/IgA2 ratio was found not to differ from controls in either groups of patients. An increase in polymeric IgA was observed in Berger's and in Schönlein-Henoch GN. Both IgA subclasses were found in mesangial deposits.

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Year:  1983        PMID: 6348756

Source DB:  PubMed          Journal:  Proc Eur Dial Transplant Assoc        ISSN: 0071-2736


  3 in total

Review 1.  The rheumatic poison: a survey of some published investigations of the immunopathogenesis of Henoch-Schönlein purpura.

Authors:  J F Knight
Journal:  Pediatr Nephrol       Date:  1990-09       Impact factor: 3.714

2.  Activation of human monocytes via their sIgA receptors.

Authors:  S Padeh; C L Jaffe; J H Passwell
Journal:  Immunology       Date:  1991-02       Impact factor: 7.397

Review 3.  Henoch-Schönlein syndrome and IgA nephropathy: a case report suggesting a common pathogenesis.

Authors:  F J Hughes; N M Wolfish; P N McLaine
Journal:  Pediatr Nephrol       Date:  1988-10       Impact factor: 3.714

  3 in total

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