Literature DB >> 2016119

Activation of human monocytes via their sIgA receptors.

S Padeh1, C L Jaffe, J H Passwell.   

Abstract

We have studied the interaction of secretory immunoglobulin A (sIgA) derived from human breast milk with human monocytes. The presence of specific sIgA receptors on the monocyte membrane was confirmed by dose-dependent inhibition of E-sIgA rosette formation and by the binding of iodinated sIgA to monocyte monolayers. Binding was dependent on both the number of monocytes, as well as the amount of [125I]sIgA, and could be inhibited by unlabelled sIgA. Incubation of monocyte monolayers in the presence of increasing concentrations of secretory IgA and F(ab')2 anti-IgA resulted in a dose-dependent increase of the oxidative burst, as measured by H2O2 production. Neither sIgA or anti-IgA alone, nor incubation of IgG with anti-IgA, had any effect on the oxidative burst. These studies indicate that human monocytes have a receptor for sIgA and that specific activation of the monocytes occurs via these receptors.

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Year:  1991        PMID: 2016119      PMCID: PMC1384482     

Source DB:  PubMed          Journal:  Immunology        ISSN: 0019-2805            Impact factor:   7.397


  35 in total

1.  THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors:  F C GREENWOOD; W M HUNTER; J S GLOVER
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

2.  Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis.

Authors:  C André; F C Berthoux; F André; J Gillon; C Genin; J C Sabatier
Journal:  N Engl J Med       Date:  1980-12-04       Impact factor: 91.245

3.  Characterization of resident glomerular cells in the rat expressing Ia determinants and manifesting genetically restricted interactions with lymphocytes.

Authors:  G F Schreiner; J M Kiely; R S Cotran; E R Unanue
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

4.  Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA.

Authors:  M W Fanger; L Shen; J Pugh; G M Bernier
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

5.  Abrogation of macrophage-dependent injury in experimental glomerulonephritis in the rabbit. Use of an antimacrophage serum.

Authors:  S R Holdsworth; T J Neale; C B Wilson
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

6.  Increased prostaglandin production by human monocytes after membrane receptor activation.

Authors:  J H Passwell; J M Dayer; E Merler
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

7.  Clearance kinetics and fate of mouse IgA immune complexes prepared with monomeric or dimeric IgA.

Authors:  A Rifai; M Mannik
Journal:  J Immunol       Date:  1983-04       Impact factor: 5.422

8.  Procoagulant activity in glomeruli and urine of rabbits with nephrotoxic nephritis.

Authors:  R C Wiggins; A Glatfelter; J Brukman
Journal:  Lab Invest       Date:  1985-08       Impact factor: 5.662

9.  A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture.

Authors:  E Pick; Y Keisari
Journal:  J Immunol Methods       Date:  1980       Impact factor: 2.303

10.  Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes.

Authors:  G Pfaffenbach; M E Lamm; I Gigli
Journal:  J Exp Med       Date:  1982-01-01       Impact factor: 14.307

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  3 in total

1.  IgA and IgG immune complexes increase human macrophage C3 biosynthesis.

Authors:  J Laufer; H Boichis; N Farzam; J H Passwell
Journal:  Immunology       Date:  1995-02       Impact factor: 7.397

Review 2.  Current status of meningococcal group B vaccine candidates: capsular or noncapsular?

Authors:  J Diaz Romero; I M Outschoorn
Journal:  Clin Microbiol Rev       Date:  1994-10       Impact factor: 26.132

3.  Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production.

Authors:  G L Polat; J Laufer; I Fabian; J H Passwell
Journal:  Immunology       Date:  1993-10       Impact factor: 7.397

  3 in total

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