Literature DB >> 6348482

2-Ketobutyrate: a putative alarmone of Escherichia coli.

J Daniel, L Dondon, A Danchin.   

Abstract

2-ketobutyrate is synthesized from threonine by threonine deaminase (dehydratase) in E. coli. The effects of 2-ketobutyrate as a regulatory metabolite were studied in vivo. 2-ketobutyrate was shown to inhibit the phosphoenolpyruvate (PEP): sugar phosphotransferase system resulting in aspartate starvation, elevation of ppGpp endogenous pools, and cessation of growth in E. coli grown in glucose and related carbon sources. Accordingly, we propose that 2-ketobutyrate might serve as an alarmone whose concentration precisely governs the shift from anaerobic growth to aerobic growth in E. coli. Such shifts are common phenomena among the Enterobacteriaceae.

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Year:  1983        PMID： 6348482     DOI： 10.1007/bf00331076

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  20 in total

1.  FINE CONTROL OF PHOSPHOPYRUVATE CARBOXYLASE ACTIVITY IN ESCHERICHIA COLI.

Authors:  J L CANOVAS; H L KORNBERG
Journal:  Biochim Biophys Acta       Date:  1965-01

2.  Correlation between the serine sensitivity and the derepressibility of the ilv genes in Escherichia coli relA- mutants.

Authors:  M Uzan; A Danchin
Journal:  Mol Gen Genet       Date:  1978-09-20

3.  The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent strains.

Authors:  M Cashel
Journal:  J Biol Chem       Date:  1969-06-25       Impact factor: 5.157

4.  Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.

Authors:  J C Stephens; S W Artz; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

5.  Phosphoryl exchange reaction catalyzed by enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Kinetic characterization.

Authors:  M H Saier; M R Schmidt; P Lin
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157

Review 6.  Carbohydrate transport in bacteria.

Authors:  S S Dills; A Apperson; M R Schmidt; M H Saier
Journal:  Microbiol Rev       Date:  1980-09

7.  Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K 12 toward serine: excretion of 2-ketobutyrate, a precursor of isoleucine.

Authors:  J Daniel; A Danchin
Journal:  Mol Gen Genet       Date:  1979-11

8.  Thin-layer chromatographic methods to isolate 32P-labeled 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP): determination of cellular PRPP pools and assay of PRPP synthetase activity.

Authors:  K F Jensen; U Houlberg; P Nygaard
Journal:  Anal Biochem       Date:  1979-10-01       Impact factor: 3.365

9.  Isoleucine and valine metabolism in Escherichia coli. VII. A negative feedback mechanism controlling isoleucine biosynthesis.

Authors:  H E UMBARGER; B BROWN
Journal:  J Biol Chem       Date:  1958-08       Impact factor: 5.157

10.  Regulation of methyl beta-galactoside permease activity in pts and crr mutants of Salmonella typhimurium.

Authors:  P W Postma; A Schuitema; C Kwa
Journal:  Mol Gen Genet       Date:  1981
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  18 in total

1.  Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium.

Authors:  George Schmitz; Diana M Downs
Journal:  J Bacteriol       Date:  2004-02       Impact factor: 3.490

2.  Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine.

Authors:  Kechun Zhang; Han Li; Kwang Myung Cho; James C Liao
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-23       Impact factor: 11.205

3.  Physiological implications of the substrate specificities of acetohydroxy acid synthases from varied organisms.

Authors:  N Gollop; B Damri; D M Chipman; Z Barak
Journal:  J Bacteriol       Date:  1990-06       Impact factor: 3.490

4.  Evidence for cAMP-mediated control of isoleucyl-tRNA synthetase formation in Escherichia coli K-12.

Authors:  A L Williams; R S Barnett
Journal:  Arch Microbiol       Date:  1985-07       Impact factor: 2.552

5.  Metabolic alterations mediated by 2-ketobutyrate in Escherichia coli K12.

Authors:  A Danchin; L Dondon; J Daniel
Journal:  Mol Gen Genet       Date:  1984

6.  Conserved pyridoxal protein that regulates Ile and Val metabolism.

Authors:  Tomokazu Ito; Jumpei Iimori; Sayuri Takayama; Akihito Moriyama; Ayako Yamauchi; Hisashi Hemmi; Tohru Yoshimura
Journal:  J Bacteriol       Date:  2013-10-04       Impact factor: 3.490

7.  Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin.

Authors:  Joanne M Kingsbury; John H McCusker
Journal:  Microbiology (Reading)       Date:  2009-12-17       Impact factor: 2.777

8.  Role of 2-ketobutyrate as an alarmone in E. coli K12: inhibition of adenylate cyclase activity mediated by the phosphoenolpyruvate: glycose phosphotransferase transport system.

Authors:  J Daniel; E Joseph; A Danchin
Journal:  Mol Gen Genet       Date:  1984

9.  Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria.

Authors:  Z Barak; D M Chipman; N Gollop
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490

10.  Isolation and kinetic properties of acetohydroxy acid isomeroreductase from spinach (Spinacia oleracea) chloroplasts overexpressed in Escherichia coli.

Authors:  R Dumas; D Job; J Y Ortholand; G Emeric; A Greiner; R Douce
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857
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